Evidence map›Paper›PMID 37872734›Full record

ArticleAnnals of clinical and translational neurology2023

T1-/T2-weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy.

Colin Denis, Kevin Dabbs, Veena A Nair, Jedidiah Mathis, Dace N Almane, Akshayaa Lakshmanan, Andrew Nencka, Rasmus M Birn, Lisa Conant, Colin Humphries and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Colin DenisDepartment of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-7479-411X
Kevin DabbsDepartment of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Veena A NairDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jedidiah MathisDepartment of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Dace N AlmaneDepartment of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Akshayaa LakshmananDepartment of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Andrew NenckaDepartment of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Rasmus M BirnDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Lisa ConantDepartment of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Colin HumphriesDepartment of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Elizabeth FeltonDepartment of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-6461-5758
Manoj RaghavanDepartment of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Edgar A DeYoeDepartment of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jeffrey R BinderDepartment of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Bruce HermannDepartment of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Vivek PrabhakaranDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Barbara B BendlinDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Mary E MeyerandDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Mélanie BolyDepartment of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Aaron F StruckDepartment of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-9103-1798
University of Wisconsin–Madison · USMedical College of Wisconsin · US

Funding

Alzheimer's Disease Connectome ProjectUF1AG051216 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI BENDLIN, BARBARA BRIGITTA, LI, SHI-JIANG · 2016 to 2019
$5.8M
The Epilepsy Connectome ProjectU01NS093650 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI BINDER, JEFFREY R, MEYERAND, MARY E. · 2015 to 2018
$5.1M
Stroke Connectome MRI Biomarkers for VCID Risk AssessmentR01NS123378 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Nagesh Adluru, Veena A Nair · 2022 to 2026
$3.6M
The Juvenile Myoclonic Epilepsy Connectome ProjectR01NS111022 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI STRUCK, AARON F · 2020 to 2024
$3.1M
PET/MR Correlates of Accelerated Aging in Chronic EpilepsyR01NS117568 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Alan Blair McMillan, Vivek Prabhakaran · 2021 to 2026
$3.0M
Stroke Rehabilitation utilizing BCI technologyR01NS105646 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI PRABHAKARAN, VIVEK · 2018 to 2022
$2.3M
NIA NIH HHS UF1 AG051216NIH HHS 1UF1AG051216-01A1NIH HHS U01NS093650NINDS NIH HHS R01 NS105646NINDS NIH HHS R01 NS111022NINDS NIH HHS R01 NS117568NINDS NIH HHS R01 NS123378NINDS NIH HHS U01 NS093650
6 · The paper itself

Abstract

Short-range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We compared T1w/T2w gray matter myelin maps between TLE patients and age-matched controls and assessed relationships between myelin and aging. While both TLE patients and healthy controls exhibited increased T1w/T2w intensity with age, we found no evidence for significant group-level aberrations in overall myelin content or myelin changes through time in TLE.

Indexed as

Epilepsy, Temporal LobeGray MatterAgingHumansMagnetic Resonance ImagingMyelin Sheath

Identifiers

PMID37872734
PMCPMC10647008
OpenAlexW4387893404

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.