ArticleBMC psychiatry2023
Analysis of the relationship between sleep-related disorder and systemic immune-inflammation index in the US population.
Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The association between hematological markers of inflammation and chronic cannabis use: a systematic review and meta-analysis of observational studies.Frontiers in psychiatry · 2024Pooled it
- The inflammation-nutrition axis and survival outcomes: Role of the neutrophil percentage-to-albumin ratio in patients with sleep disorders.The Journal of international medical research · 2026Article
- J-shaped relationship between physical activity and frailty risk in adults with sleep disorders: the additional protective role of the weekend warrior pattern.Scientific reports · 2026Article
- Association of nighttime sleep duration and quality with low back pain in middle-aged and elderly Chinese: a nationwide longitudinal cohort study.BMC public health · 2026Article
- The combined impact of social isolation and unhealthy risk score on mortality risk: a study from two prospective cohorts.BMC public health · 2026Article
- Association between systemic immune-inflammatory index and circadian syndrome: Data from NHANES 2005 to 2018.Medicine · 2026Article
- Relationship between insomnia and cognitive function in elderly Chinese cerebral small vessel disease patients: mediating effect of neutrophil-to-lymphocyte ratio.Frontiers in psychiatry · 2026Article
- Association of Complete Blood Count-Derived Inflammatory Markers with Trouble Sleeping: Evidence from Population Data and Experimental Sleep Deprivation.Nature and science of sleep · 2026Article
- A novel integrated inflammation response score (IIRS) for predicting all-cause and cardiovascular mortality among cancer survivors.American journal of cancer research · 2026Article
- Therapeutic nutrition strategies for the shared pathophysiology of obesity and sleep-disordered breathings.Nutrition journal · 2025Review
- Article
- A [Journal of neuroinflammation · 2025Article
- Assessing the association between multiple indicators of inflammation and sleep disorders in young and middle-aged women: insights from traditional and machine learning approaches.European journal of medical research · 2025Article
- Bidirectional Mendelian randomization analysis of inflammatory factors and sleep related traits.Brain, behavior, & immunity - health · 2025Article
- Associations Among Sleep Duration, Sleep Quality, and Age-Related Ocular Diseases: Insights From Longitudinal and Mediation Analyses.Investigative ophthalmology & visual science · 2025Article
- Spatial analysis of the percentages of smokers, alcohol drinkers, social welfare expenditure and insomniacs in Japan.Scientific reports · 2025Article
- Sleep disturbance and hypertension mediated by systemic inflammatory response index in NHANES.Scientific reports · 2025Article
- Molecular Insights into the Interaction of Orexin 1 Receptor Antagonists: A Comprehensive Study Using Classical and Quantum Computational Methods.Molecules (Basel, Switzerland) · 2025Article
- Occupational but not leisure-time physical activity associated with high-risk of obstructive sleep apnea status: a population-based study.BMC pulmonary medicine · 2025Article
- Relationship between inflammatory factors, lactic acid levels, acute skin failure, bad mood, and sleep quality.World journal of psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between sleep-related disorders and inflammation has been demonstrated in previous studies. The systemic immune-inflammation index (SII) is a novel inflammatory index based on leukocytes, but its relationship with sleep-related disorder is unclear. We aimed to investigate the relationship between sleep-related disorder and SII in a nationally representative nonhospitalized sample.
methodsData were obtained from the 2005-2008 National Health and Nutrition Examination Survey (NHANES). Exposure variables included self-reported sleep-related disorders, such as sleep duration, sleep problems, high risk of OSA, and daytime sleepiness. SII and other traditional markers of inflammation were considered as outcome variables, including platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR). Multiple linear regression models were employed to examine the correlation between sleep-related disorders and inflammatory markers. Subgroup interactions were analyzed using likelihood ratio tests, and nonlinear relationships were explored by fitting restricted cubic splines.
resultsA total of 8,505 participants were enrolled in this study. Overall, sleep-related disorders were found to have a stronger association with SII compared to the PLR and NLR. The results of multiple linear regression analysis revealed that participants who experienced sleep problems (β: 21.421; 95% CI 1.484, 41.358), had symptoms of OSA (β: 23.088; 95% CI 0.441, 45.735), and reported daytime sleepiness (β: 30.320; 95% CI 5.851, 54.789) exhibited a positive association with higher SII. For the analysis of other inflammatory markers, we only found that daytime sleepiness was associated with increased NLR levels (β: 0.081; 95% CI 0.002, 0.159).
conclusionSleep problems, symptoms of OSA, and daytime sleepiness were found to have a positive association with the SII in US adults. However, further prospective studies are necessary to establish whether there is a causal relationship between these factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.