ArticleGenome biology2023
aMeta: an accurate and memory-efficient ancient metagenomic profiling workflow.
Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Ground squirrel coprolites preserve complex archives of ancient environmental DNA over 700,000 years.Nature communications · 2026Article
- Insights into infectious diseases through ancient pathogen genomics.Nature reviews. Microbiology · 2026Review
- Analysis of medieval burials from Ibiza reveals genetic and pathogenic diversity during the Islamic period.Nature communications · 2026Article
- Recent Microbial Evolutionary Insights From Metagenomics.Genome biology and evolution · 2026Review
- Setting higher standards for reports of microbial species in human cancers.Nature cancer · 2026Review
- Genetic affinities between the ancient Greek colony of Amvrakia and its metropolis.Genome biology · 2026Article
- How low can you go? Establishing detection limits for rare eukaryotes in Southern Ocean sedimentary ancient DNA.Bioinformatics advances · 2026Article
- Histological and metagenomic analysis of microbial communities in archaeological human bones.PloS one · 2026Article
- Refining filtering criteria of Kraken family of tools for accurate taxonomic profiling of ancient metagenomic data.Frontiers in microbiology · 2026Article
- Comparative assessment of SNP genotyping assays for challenging forensic samples utilizing ancient DNA methods.Genome biology · 2025Article
- Ancient DNA sheds light on the historical distribution of the rare and ephemeral plant Coleanthus subtilis in Southern Siberia.BMC genomics · 2025Article
- Bamdam: a post-mapping authentication toolkit for ancient metagenomics.Genome biology · 2025Article
- Quick Analysis of Sedimentary Ancient DNA Using quicksand.Molecular biology and evolution · 2025Article
- CarpeDeam: a de novo metagenome assembler for heavily damaged ancient datasets.Genome biology · 2025Article
- ParaRef: a decontaminated reference database for parasite detection in ancient and modern metagenomic datasets.Genome biology · 2025Article
- Small Bugs, Big Data: Metagenomics for Arthropod Biodiversity Monitoring.Ecology and evolution · 2025Article
- AdDeam: a fast and scalable tool for estimating and clustering reference-level damage profiles.Bioinformatics (Oxford, England) · 2025Article
- Improving taxonomic inference from ancient environmental metagenomes by masking microbial-like regions in reference genomes.GigaScience · 2025Article
- Unraveling the ancient fungal DNA from the Iceman gut.BMC genomics · 2024Article
- Oral microbial diversity in 18th century African individuals from South Carolina.Communications biology · 2024Article
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Authors and funding
13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Analysis of microbial data from archaeological samples is a growing field with great potential for understanding ancient environments, lifestyles, and diseases. However, high error rates have been a challenge in ancient metagenomics, and the availability of computational frameworks that meet the demands of the field is limited. Here, we propose aMeta, an accurate metagenomic profiling workflow for ancient DNA designed to minimize the amount of false discoveries and computer memory requirements. Using simulated data, we benchmark aMeta against a current state-of-the-art workflow and demonstrate its superiority in microbial detection and authentication, as well as substantially lower usage of computer memory.
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