Evidence map›Paper›PMID 37872485›Full record

ArticleBMC infectious diseases2023

Biliary sepsis complication with congenital hepatic fibrosis: an unexpected outcome.

Jiawei Sun, Xiaoxiao Mi, Xiaoying Ye, Yiling ShenTu, Chun Liu, Dong Tang, WenJun Yang, Jie Yang, Xiaoping Ye, Xiaojie Ma and 3 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jiawei Sun *Hangzhou Normal University, Zhejiang, China.
Xiaoxiao Mi *Institute of Translational Medicine, The Affiliated Hospital of Hangzhou Normal University, Zhejiang, China.
Xiaoying YeHangzhou Normal University, Zhejiang, China.
Yiling ShenTuDepartment of Respiratory Medicine, Fuyang First People's Hospital, Hangzhou, China.
Chun LiuHangzhou Normal University, Zhejiang, China.
Dong TangDepartment of Medical Imaging (Radiology), The Affiliated Hospital of Hangzhou Normal University, Zhejiang, China.
WenJun YangDepartment of Pathology, The Affiliated Hospital of Hangzhou Normal University, Zhejiang, China.
Jie YangDepartment of Infectious Disease (Liver Diseases), Lishui Municipal Central Hospital, Zhejiang, China.
Xiaoping YeDepartment of Infectious Disease (Liver Diseases), The Affiliated Hospital of Hangzhou Normal University, Zhejiang, 310015, China.
Xiaojie MaDepartment of Infectious Disease (Liver Diseases), The Affiliated Hospital of Hangzhou Normal University, Zhejiang, 310015, China.
Junping ShiDepartment of Infectious Disease (Liver Diseases), The Affiliated Hospital of Hangzhou Normal University, Zhejiang, 310015, China.
Gongying ChenDepartment of Infectious Disease (Liver Diseases), The Affiliated Hospital of Hangzhou Normal University, Zhejiang, 310015, China.
Ling GongDepartment of Infectious Disease (Liver Diseases), The Affiliated Hospital of Hangzhou Normal University, Zhejiang, 310015, China. gongllyy@hznu.edu.cn.
Affiliated Hospital of Hangzhou Normal University · CNHangzhou Normal University · CNLishui Central Hospital · CN

Funding

Department of Health of Zhejiang Province No.2022KY964National Natural Science Foundation of China No. 82100614Natural Science Foundation of Zhejiang Province No. LBY21H030001
6 · The paper itself

Abstract

backgroundCHF (Congenital hepatic fibrosis) is a rare hereditary disease characterized by periportal fibrosis and ductal plate malformation. Little is known about the clinical presentations and outcome in CHF patients with an extraordinary complication with biliary sepsis. Our case described a 23-year-old female diagnosed as CHF combined with biliary sepsis. Her blood culture was positive for KP (Klebsiella pneumoniae), and with a high level of CA19-9 (> 1200.00 U/ml, ref: <37.00 U/ml). Meanwhile, her imaging examinations showed intrahepatic bile duct dilatation, portal hypertension, splenomegaly, and renal cysts. Liver pathology revealed periportal fibrosis and irregularly shaped proliferating bile ducts. Whole-exome sequencing identified two heterozygous missense variants c.3860T > G (p. V1287G) and c.9059T > C (p. L3020P) in PKHD1 gene. After biliary sepsis relieved, her liver function test was normal, and imaging examination results showed no significant difference with the results harvested during her biliary sepsis occurred.

conclusionThe diagnosis of CHF complicated with biliary sepsis in the patient was made. Severely biliary sepsis due to KP infection may not inevitably aggravate congential liver abnormality in young patients. Our case provides a good reference for timely treatment of CHF patients with biliary sepsis.

Indexed as

Bile Duct DiseasesLiver DiseasesSepsisFemaleGenetic Diseases, InbornHumansLiver CirrhosisYoung AdultBiliary sepsisCongenital hepatic fibrosisKlebsiella pneumoniaePKHD1

Identifiers

PMID37872485
PMCPMC10591346
OpenAlexW4387879128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.