Evidence map›Paper›PMID 37872462›Full record

ArticleMolecular imaging and biology2023

Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study.

Alice Petty, Anna Garcia-Hidalgo, Els F Halff, Sridhar Natesan, Dominic J Withers, Elaine E Irvine, Michelle Kokkinou, Lisa A Wells, David R Bonsall, Sac-Pham Tang and 2 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Alice PettyFaculty of Medicine, Imperial College London, Institute of Clinical Sciences, London, UK. a.petty@lms.mrc.ac.uk.ORCID 0000-0001-7058-4185
Anna Garcia-HidalgoFaculty of Medicine, Imperial College London, Institute of Clinical Sciences, London, UK.
Els F HalffPsychiatric Imaging Group, MRC London Institute of Medical Sciences, London, UK.
Sridhar NatesanPsychiatric Imaging Group, MRC London Institute of Medical Sciences, London, UK.
Dominic J WithersFaculty of Medicine, Imperial College London, Institute of Clinical Sciences, London, UK.
Elaine E IrvineFaculty of Medicine, Imperial College London, Institute of Clinical Sciences, London, UK.
Michelle KokkinouFaculty of Medicine, Imperial College London, Institute of Clinical Sciences, London, UK.
Lisa A WellsInvicro, Burlington Danes, Hammersmith Hospital, London, UK.
David R BonsallInvicro, Burlington Danes, Hammersmith Hospital, London, UK.
Sac-Pham TangInvicro, Burlington Danes, Hammersmith Hospital, London, UK.
Mattia VeroneseDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Oliver D HowesFaculty of Medicine, Imperial College London, Institute of Clinical Sciences, London, UK.
MRC London Institute of Medical Sciences · GBHammersmith Hospital · GBKing's College London · GBLundbeck (Denmark) · DKUniversity of Padua · IT

Funding

Medical Research CouncilWellcome Trust
6 · The paper itself

Abstract

purposeThere is robust evidence that people with schizophrenia show elevated dopamine (DA) synthesis capacity in the striatum. This finding comes from positron emission tomography (PET) studies using radiolabelled l-3,4-dihydroxyphenylalanine ( PROCEDURES: Adult male C57Bl6 mice were treated daily with either ketamine (30 mg/kg, i.p.) or vehicle (saline) for 5 days. On day 7, animals were administered

resultsUsing an atlas-based template to position the 3.7 mm

conclusionsUsing this optimised method for quantifying

Indexed as

DopamineKetamineAdultAnimalsCorpus StriatumDihydroxyphenylalanineHumansMaleMesencephalonMiceMice, Inbred C57BLPositron-Emission TomographyPositron Emission Tomography Computed TomographyDihydroxyphenylalanineDopaminefluorodopa F 18KetamineDopamineF-DOPAKetamineMidbrainPETPreclinicalSchizophrenia

Identifiers

PMID37872462
PMCPMC10728236
OpenAlexW4387874002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.