Evidence map›Paper›PMID 37872359›Full record

ArticleScientific reports2023

Experimental pathogenesis of aquatic bird bornavirus 1 in Pekin ducks.

Fernanda Ampuero, Alexander Leacy, Phuc H Pham, Sunoh Che, Claire Jardine, Eva Nagy, Pauline Delnatte, Brandon N Lillie, Leonardo Susta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. The First Genetic Characterization of theAnimals : an open access journal from MDPI · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Fernanda AmpueroPathobiology Department, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Alexander LeacyPathobiology Department, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Phuc H PhamPathobiology Department, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Sunoh ChePathobiology Department, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Claire JardinePathobiology Department, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Eva NagyPathobiology Department, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Pauline DelnattePathobiology Department, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Brandon N LilliePathobiology Department, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Leonardo SustaPathobiology Department, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada. lsusta@uoguelph.ca.
University of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aquatic bird bornavirus 1 (ABBV-1) is a neurotropic virus that causes persistent infection in the nervous system of wild waterfowl. This study evaluated whether Pekin ducks, the most common waterfowl raised worldwide, are susceptible to ABBV-1 infection and associated disease. Groups of Pekin ducks were inoculated with ABBV-1 through the intracranial (IC; n, 32), intramuscular (IM; n, 30), and choanal (CH; n, 30) routes. Controls (CO; n, 29) received carrier only. At 1, 12, and 21 weeks postinfection (wpi), 7-14 birds were euthanized to assess virus distribution and lesions. Infection rates in the IC and IM groups were over 70%, while only 4 ducks in the CH group became infected. Neurological signs were observed in 8 ducks only, while over 25% of IC and IM birds had encephalitis and/or myelitis. Seroconversion was highest in the IC and IM groups, and mucosal ABBV-1 RNA shedding was most frequent in the IC group (53%). None of the fertile eggs laid during the experiment tested positive for ABBV-1 RNA. This study shows that Pekin ducks are permissive to ABBV-1 infection and partly susceptible to associated disease. While mucosal shedding may be an important route of transmission, congenital infection appears unlikely.

Indexed as

Influenza in BirdsRNA VirusesAnimalsDucksRNARNA

Identifiers

PMID37872359
PMCPMC10593797
OpenAlexW4387879751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.