Evidence map›Paper›PMID 37872244›Full record

ReviewNature methods2023

Artificial intelligence-enabled quantitative phase imaging methods for life sciences.

Juyeon Park, Bijie Bai, DongHun Ryu, Tairan Liu, Chungha Lee, Yi Luo, Mahn Jae Lee, Luzhe Huang, Jeongwon Shin, Yijie Zhang and 6 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
  2. Review
  3. Intelligent Stain-Free Histology on Structural Colorimetric Nanocavities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  6. Virtual histology imaging of lymph nodesCancer biology & medicine · 2026
    Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Gradient Descent to Predict Enzyme Inhibition.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Juyeon Park *Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Bijie Bai *Electrical and Computer Engineering Department, University of California, Los Angeles, Los Angeles, CA, USA.
DongHun RyuDepartment of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Tairan LiuElectrical and Computer Engineering Department, University of California, Los Angeles, Los Angeles, CA, USA.
Chungha LeeDepartment of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Yi LuoElectrical and Computer Engineering Department, University of California, Los Angeles, Los Angeles, CA, USA.
Mahn Jae LeeKAIST Institute for Health Science and Technology, KAIST, Daejeon, Republic of Korea.
Luzhe HuangElectrical and Computer Engineering Department, University of California, Los Angeles, Los Angeles, CA, USA.
Jeongwon ShinKAIST Institute for Health Science and Technology, KAIST, Daejeon, Republic of Korea.
Yijie ZhangElectrical and Computer Engineering Department, University of California, Los Angeles, Los Angeles, CA, USA.
Dongmin RyuTomocube, Daejeon, Republic of Korea.
Yuzhu LiElectrical and Computer Engineering Department, University of California, Los Angeles, Los Angeles, CA, USA.
Geon KimDepartment of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Hyun-Seok MinTomocube, Daejeon, Republic of Korea.ORCID 0000-0002-7435-7884
Aydogan OzcanElectrical and Computer Engineering Department, University of California, Los Angeles, Los Angeles, CA, USA. ozcan@ucla.edu.ORCID 0000-0002-0717-683X
YongKeun ParkDepartment of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. yk.park@kaist.ac.kr.ORCID 0000-0003-0528-6661

Funding

National Research Foundation of Korea (NRF) 2015R1A3A2066550
6 · The paper itself

Abstract

Quantitative phase imaging, integrated with artificial intelligence, allows for the rapid and label-free investigation of the physiology and pathology of biological systems. This review presents the principles of various two-dimensional and three-dimensional label-free phase imaging techniques that exploit refractive index as an intrinsic optical imaging contrast. In particular, we discuss artificial intelligence-based analysis methodologies for biomedical studies including image enhancement, segmentation of cellular or subcellular structures, classification of types of biological samples and image translation to furnish subcellular and histochemical information from label-free phase images. We also discuss the advantages and challenges of artificial intelligence-enabled quantitative phase imaging analyses, summarize recent notable applications in the life sciences, and cover the potential of this field for basic and industrial research in the life sciences.

Indexed as

Artificial IntelligenceBiological Science DisciplinesImage EnhancementImaging, Three-Dimensional

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.