SynthesisScientific reports2023
Effectiveness of exercise interventions to improve long-term outcomes in people living with mild cognitive impairment: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Comparative effectiveness of rhythmic grip training of various intensities on cognitive function in young adults: a fNIRS study.Frontiers in neuroscience · 2025Trial
- Efficacy of sequential aerobic exercise and cognitive training in older adults with amnestic mild cognitive impairment.Aging and health research · 2026Article
- Exercise-based modulation of the gut-brain axis: a new direction for neurorehabilitation in Alzheimer's disease.Frontiers in aging neuroscience · 2026Review
- Reporting randomised trials of physical exercise or training interventions in older adults: the PETIO guideline.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Prevention of cognitive impairment and dementia in people with Parkinson's disease: A call-to-action.Journal of Parkinson's disease · 2025Review
- Exploring the potential relationship between kidney disease index and cognitive dysfunction: a machine learning approach with NHANES data.BMC geriatrics · 2025Article
- One-year exercise improves cognition and fitness and decreases vascular stiffness and reactivity to CO2 in amnestic mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Article
- Comparative effectiveness of open and closed skill exercises on cognitive function in young adults: a fNIRS study.Scientific reports · 2024Observational
- Management of MCI in the Outpatient Setting.Current psychiatry reports · 2024Review
- Physical Activity and Cognitive Functioning.Medicina (Kaunas, Lithuania) · 2024Review
- Associations of oxidative balance score and cognition in US older adults: A cross-sectional study of National Health and Nutrition Examination Survey (NHANES) 2011 to 2014.Journal of Alzheimer's disease reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although exercise guidelines now recommend exercise for patients with MCI, the long-term effects of exercise in patients with MCI has not been reviewed systematically. The aim was to assess (1) the effectiveness of exercise and physical activity (EXPA) interventions in improving long-term patient-relevant cognitive and non-cognitive outcomes in people with mild cognitive impairment, (2) how well the included trials reported details of the intervention, and (3) the extent to which reported endpoints were in line with patient preferences that were assessed in patient workshops. Following PRISMA guidelines, we performed a systematic review and meta-analysis including randomized controlled trials. A total of ten studies were included after searching in six electronic sources from 1995 onwards. There is a trend that 6 + -month EXPA interventions improve global cognition 12 months after initiation. Evidence on long-term effects of EXPA interventions on non-cognitive health outcomes could not be meaningfully pooled and the individual studies reported mixed results. Workshop participants considered freedom from pain and stress, mood, motivation and self-efficacy to be important, but these outcomes were rarely addressed. Too little information is available on intervention details for EXPA programs to be replicated and confidently recommended for patients with MCI. PROSPERO registration in December, 2021 (CRD42021287166).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.