ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
Dissociating the Contributions of Frontal Eye Field Activity to Spatial Working Memory and Motor Preparation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 24 citations in OpenAlex.
- Differential Coding of Associative Memory Information in the Macaque Lateral Prefrontal Cortex and Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Inferring latent behavioral strategy from the representational geometry of prefrontal cortex activity.Nature communications · 2026Article
- Working Memory of Multi-Object Scenes in Primate Frontal Cortex.bioRxiv : the preprint server for biology · 2026Article
- Population-Level Activity Dissociates Preparatory Overt from Covert Attention.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Prefrontal contributions to the executive control of visuospatial working memory across primate species.Frontiers in neuroanatomy · 2026Review
- Integrating memory-guided saccades and EEG for MCI screening: a multimodal LASSO modeling approach.Frontiers in aging neuroscience · 2026Article
- Exploring the interrelationships among physical exercise, visuospatial working memory, and depression symptoms in university students.Scientific reports · 2025Article
- Perisaccadic Attentional Updating in Area V4: A Neurocomputational Approach.The European journal of neuroscience · 2025Article
- Sensory reformatting for a working visual memory.Trends in cognitive sciences · 2025Review
- Flexible Use of Limited Resources for Sequence Working Memory in Macaque Prefrontal Cortex.Nature communications · 2025Article
- Marmoset Anterior Cingulate Area 32 Neurons Exhibit Responses to Presented and Produced Calls during Naturalistic Vocal Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Working Memory Updating in the Macaque Lateral Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Associations between neuropsychological profile and regional brain FDG uptake in progressive supranuclear palsy.Journal of Parkinson's disease · 2025Article
- Robust encoding of stimulus-response mapping by neurons in visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Common and distinct neural mechanisms of attention.Trends in cognitive sciences · 2024Review
- Cell type-specific connectome predicts distributed working memory activity in the mouse brain.eLife · 2024Article
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3 authors at 3 institutions in 1 country.
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Abstract
Neurons within dorsolateral prefrontal cortex (PFC) of primates are characterized by robust persistent spiking activity exhibited during the delay period of working memory tasks. This includes the frontal eye field (FEF) where nearly half of the neurons are active when spatial locations are held in working memory. Past evidence has established the FEF's contribution to the planning and triggering of saccadic eye movements as well as to the control of visual spatial attention. However, it remains unclear whether persistent delay activity reflects a similar dual role in movement planning and visuospatial working memory. We trained male monkeys to alternate between different forms of a spatial working memory task which could dissociate remembered stimulus locations from planned eye movements. We tested the effects of inactivation of FEF sites on behavioral performance in the different tasks. Consistent with previous studies, FEF inactivation impaired the execution of memory-guided saccades (MGSs), and impaired performance when remembered locations matched the planned eye movement. In contrast, memory performance was largely unaffected when the remembered location was dissociated from the correct eye movement response. Overall, the inactivation effects demonstrated clear deficits in eye movements, regardless of task type, but little or no evidence of a deficit in spatial working memory. Thus, our results indicate that persistent delay activity in the FEF contributes primarily to the preparation of eye movements and not to spatial working memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.