ArticleJournal of advanced research2024
P450Rdb: A manually curated database of reactions catalyzed by cytochrome P450 enzymes.
Article in Journal of advanced research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Comprehensive Characterization of Cytochrome P450s Reveals Candidate Enzymes Involved in the Metabolic Fate of Absorbed Volatile Organic Compounds in Potato.Antioxidants (Basel, Switzerland) · 2026Article
- Rethinking bioinformatics in liquid-liquid phase separation: data resources, predictive models, and an event-centric perspective.Briefings in bioinformatics · 2026Review
- Copper-Iron Cell Death Axis: Mechanistic Crosstalk, Disease Implications and an Integrated Metallo-Redox-Metabolic Framework.International journal of biological sciences · 2026Review
- MetaCYP: a unified framework for prediction of cytochrome P450 metabolic sites and reaction types via multimodal deep learning.Frontiers in chemistry · 2026Article
- Multi-omics integrative analysis reveals novel genetic loci and candidate genes for ischemic stroke.Molecular therapy. Nucleic acids · 2025Article
- Computational toxicology in drug discovery: applications of artificial intelligence in ADMET and toxicity prediction.Briefings in bioinformatics · 2025Review
- Insights into angiosperm evolution and lineage-specialized lignan biosynthesis from the early-divergingScience advances · 2025Article
- LSA-DDI: Learning Stereochemistry-Aware Drug Interactions via 3D Feature Fusion and Contrastive Cross-Attention.International journal of molecular sciences · 2025Article
- An artificial intelligence-based approach for identifying the proteins regulating liquid-liquid phase separation.Briefings in bioinformatics · 2025Article
- Telomere-to-telomere genome assembly and 3D chromatin architecture ofHorticulture research · 2025Article
- Review
- Properties of "Stable" Mosquito Cytochrome P450 Enzymes.Insects · 2025Article
- The complete genome assembly of Astragalus membranaceus: enabling more accurate genetic research.GigaScience · 2025Article
- Investigation ofComputational and structural biotechnology journal · 2024Review
- Identification of CCR7 and CBX6 as key biomarkers in abdominal aortic aneurysm: Insights from multi-omics data and machine learning analysis.IET systems biology · 2024Article
- Human essential gene identification based on feature fusion and feature screening.IET systems biology · 2024Article
- siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database.IET systems biology · 2024Article
- Comprehensive Review on Plant Cytochrome P450 Evolution: Copy Number, Diversity, and Motif Analysis From Chlorophyta to Dicotyledoneae.Genome biology and evolution · 2024Review
- Biological Characteristics of the Cytochrome P 450 Family and the Mechanism of Terpinolene Metabolism inInternational journal of molecular sciences · 2024Article
- iGATTLDA: Integrative graph attention and transformer-based model for predicting lncRNA-Disease associations.IET systems biology · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCytochrome P450 enzymes (P450s) are recognized as the most versatile catalysts worldwide, playing vital roles in numerous biological metabolism and biosynthesis processes across all kingdoms of life. Despite the vast number of P450 genes available in databases (over 300,000), only a small fraction of them (less than 0.2 %) have undergone functional characterization.
objectivesTo provide a convenient platform with abundant information on P450s and their corresponding reactions, we introduce the P450Rdb database, a manually curated resource compiles literature-supported reactions catalyzed by P450s.
methodsAll the P450s and Reactions were manually curated from the literature and known databases. Subsequently, the P450 reactions organized and categorized according to their chemical reaction type and site. The website was developed using HTML and PHP languages, with the MySQL server utilized for data storage.
resultsThe current version of P450Rdb catalogs over 1,600 reactions, involving more than 590 P450s across a diverse range of over 200 species. Additionally, it offers a user-friendly interface with comprehensive information, enabling easy querying, browsing, and analysis of P450s and their corresponding reactions. P450Rdb is free available at http://www.cellknowledge.com.cn/p450rdb/.
conclusionsWe believe that this database will significantly promote structural and functional research on P450s, thereby fostering advancements in the fields of natural product synthesis, pharmaceutical engineering, biotechnological applications, agricultural and crop improvement, and the chemical industry.
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