Evidence map›Paper›PMID 37871625›Full record

ArticleThe Journal of international medical research2023

Aldehyde dehydrogenase 2 gene rs671 G>A polymorphism is associated with an increased risk of digestive tract cancer.

Yang Yang, Qun Liang, Yijin Chen, Yu Cao, Qingqing Zhuo, Boying Liu, Shengbing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yang YangDepartment of Gastroenterology, Meizhou People's Hospital, Meizhou, China.ORCID 0000-0002-9762-1473
Qun LiangDepartment of Gastroenterology, Meizhou People's Hospital, Meizhou, China.
Yijin ChenDepartment of Gastroenterology, Meizhou People's Hospital, Meizhou, China.
Yu CaoDepartment of Gastrointestinal Surgery, Meizhou People's Hospital, Meizhou, China.
Qingqing ZhuoDepartment of Gastroenterology, Meizhou People's Hospital, Meizhou, China.
Boying LiuDepartment of Gastroenterology, Meizhou People's Hospital, Meizhou, China.
Shengbing WangDepartment of Gastroenterology, Meizhou People's Hospital, Meizhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAcetaldehyde can accumulate in cells and form acetaldehyde-DNA adducts that result in digestive tract cancer development. Acetaldehyde dehydrogenase 2 (ALDH2) enzymatic activity is involved in this process. Here, we aimed to analyze the relationship between an

methodsThis was a retrospective study, with the

resultsOverall, 307 cancer patients and 317 controls were included. The cancer patients had significantly higher percentages with a history of smoking and drinking alcohol, as well as an increased platelet to lymphocyte ratio and lower lymphocyte to monocyte ratio, compared with the controls. The

conclusions

Indexed as

Gastrointestinal NeoplasmsPolymorphism, GeneticAcetaldehydeAlcohol DrinkingAldehyde Dehydrogenase, MitochondrialGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideRetrospective StudiesRisk FactorsAcetaldehydeAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanAldehyde dehydrogenase 2biomarkerdigestive tract cancergene polymorphismgenotypeHakka

Identifiers

PMID37871625
PMCPMC10594971

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.