SynthesisThe Journal of international medical research2023
Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis.
Synthesis in The Journal of international medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Whole-slide mapping of tumor tissue fiber architecture via computational scattered light imaging.Biomedical optics express · 2026Article
- Optimizing outcomes: a decision-analysis model for oral cancer patients with surgical margins of 1 to 5 mm.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Prognostic Role of Worst Pattern of Invasion in Oral Squamous Cell Carcinoma.Journal of clinical medicine · 2026Review
- Low ALDH1A1 expression in relation to nodal metastasis and survival in tongue squamous cell carcinoma.PloS one · 2026Article
- MRI radiomics-based predictive modeling for risk stratification and prognostication in oral tongue carcinoma.Frontiers in oncology · 2026Article
- Epidemiological evolution of gingival cancer in Spain from 2001 to 2022: a longitudinal study.Medicina oral, patologia oral y cirugia bucal · 2025Article
- A novel method for histopathological analysis of oral squamous cell carcinoma: a pilot study using three-dimensional imaging to enhance local control.Frontiers in oncology · 2025Article
- The impact of tumor budding and single-cell invasion on survival in patients with stage III/IV locally advanced oral squamous cell carcinoma- results from a prospective cohort study.Frontiers in oncology · 2024Article
- Association of worst pattern of invasion and depth of invasion in oral squamous cell carcinoma with clinicopathological parameters.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe relationship between the worst pattern of invasion (WPOI) and the prognosis of oral squamous cell carcinoma (OSCC) remains controversial. This systematic review and meta-analysis was performed to determine the impact of the WPOI on the prognosis of OSCC.
methodsStudies from six databases were assessed for quality using the Newcastle-Ottawa Scale, and data were analyzed using Stata software.
resultsEighteen studies involving 3954 patients showed that patients with a WPOI of 4 to 5 had significantly worse overall survival, disease-specific survival, and disease-free survival than patients with a WPOI of 1 to 3. Significant associations of the WPOI with locoregional recurrence and mortality were found.
conclusionA higher WPOI was significantly associated with a worse prognosis of OSCC across various outcomes. Incorporating the WPOI into standard histopathological assessments may guide personalized treatments and improve outcomes.
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