Evidence map›Paper›PMID 37871278›Full record

ArticleEpigenetics2023

Epigenome-wide association study of systemic effects of obesity susceptibility in human twins.

Glen E Duncan, Ally Avery, Millissia Ben Maamar, Eric E Nilsson, Daniel Beck, Michael K Skinner

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Glen E DuncanDepartment of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Ally AveryDepartment of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Millissia Ben MaamarCenter for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA.
Eric E NilssonCenter for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA.
Daniel BeckCenter for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA.
Michael K SkinnerCenter for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA.
Washington State University · USWashington State University Spokane · US

Funding

TWINStudy of Environment, Lifestyle Behaviors and HealthR56AG042176 · NIA · WASHINGTON STATE UNIVERSITY · PI DUNCAN, GLEN E · 2017 to 2017
$690k
NIA NIH HHS R56 AG042176
6 · The paper itself

Abstract

The current study was designed to use an epigenome-wide association approach (EWAS) to identify potential systemic DNA methylation alterations that are associated with obesity using 22 discordant twin pairs. Buccal cells (from a cheek swab) were used as a non-obesity relevant purified marker cell for the epigenetic analysis. Analysis of differential DNA methylation regions (DMRs) was used to identify epigenetic associations with metabolic and dietary measures related to obesity with discordant twins. An edgeR analysis provided a DMR signature with

Indexed as

Epigenesis, GeneticEpigenomeDNA MethylationGenome-Wide Association StudyHumansMouth MucosaObesityTwins, MonozygoticDNA methylationepigeneticsEWASobesityTwinWGCNA

Identifiers

PMID37871278
PMCPMC10595392
OpenAlexW4387871307

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.