Evidence map›Paper›PMID 37871131›Full record

ReviewAnnual review of pathology2024

ENPP1 in Blood and Bone: Skeletal and Soft Tissue Diseases Induced by ENPP1 Deficiency.

Carlos R Ferreira, Thomas O Carpenter, Demetrios T Braddock

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
10.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
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  7. The effects of elevated phosphate on the kidney - damaging the gatekeeper.Pflugers Archiv : European journal of physiology · 2026
    Review
  8. Article
  9. Hypophosphatasia-pathophysiological understanding, preclinical data looking beyond the skeleton, and upcoming treatments.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Soft tissue calcifications in chronic kidney disease-beyond the vasculature.Pflugers Archiv : European journal of physiology · 2025
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Impact of theFrontiers in endocrinology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Carlos R FerreiraMetabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Thomas O CarpenterDepartment of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.
Demetrios T BraddockDepartment of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA; email: demetrios.braddock@yale.edu.
Yale University · USNational Institutes of Health · US

Funding

Skeletal GenomicsZIAHG200407 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI FERREIRA, CARLOS · 2020 to 2024
$3.7M
ENPP1 regulation of mammalian bone massR01AR080416 · NIAMS · YALE UNIVERSITY · PI DEMETRIOS BRADDOCK · 2022 to 2026
$2.3M
ENZYME THERAPY FOR CKD-MBD: BREAKING THE BARRIER OF VASCULAR CALCIFICATIONR01DK121326 · NIDDK · YALE UNIVERSITY · PI BRADDOCK, DEMETRIOS · 2020 to 2022
$680k
Intramural NIH HHS ZIA HG200407NIAMS NIH HHS R01 AR080416NIDDK NIH HHS R01 DK121326
6 · The paper itself

Abstract

The enzyme ectonucleotide pyrophosphatase/phosphodiesterase 1 (

Indexed as

Phosphoric Diester HydrolasesVascular CalcificationAdultHumansMiddle AgedPyrophosphatasesPhosphoric Diester HydrolasesPyrophosphatasesARHR2autosomal recessive hypophosphatemic rickets type 2DISHdystrophic idiopathic spinal hyperostosisectonucleotide pyrophosphatase/phosphodiesterase 1ENPP1 deficiencyenthesopathyGACIgeneralized arterial calcification of infancyOPLLossification of the posterior longitudinal ligamentpseudoxanthoma elasticumPXE

Identifiers

PMID37871131
PMCPMC11062289
OpenAlexW4387873204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.