ArticlePLoS computational biology2023
The role of leptomeningeal collaterals in redistributing blood flow during stroke.
Article in PLoS computational biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 15 citations in OpenAlex.
- Loss of cerebral autoregulation drives abnormal perfusion patterns after stroke.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A combined extract ofJournal of ginseng research · 2026Article
- Investigating Leptomeningeal Anastomoses' Role in Collateral Blood Flow using SPECT and 4D Flow MRI.Annals of biomedical engineering · 2026Article
- Genetic determinants of insufficiency of the collateral circulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Commentary on "Multiple cortical watershed infarctions following bacterial meningitis".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Computational fluid dynamics assessment of altered hemodynamics in the Circle of Willis during acute ischemic stroke and the impact of cerebral collateral development.Biomechanics and modeling in mechanobiology · 2026Article
- Spatial and Temporal Assessment of Cerebral Blood Flow in a Novel Piglet Model of Neonatal Arterial Ischemic Stroke.Translational stroke research · 2025Article
- Blood Flow Simulation and Uncertainty Quantification in Extensive Microvascular Networks: Application to Brain Cortical Networks.Microcirculation (New York, N.Y. : 1994) · 2025Article
- Immature Acta2Nature communications · 2025Article
- Depth-dependent contributions of various vascular zones to cerebral autoregulation and functional hyperemia: An in-silico analysis.PloS one · 2025Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptomeningeal collaterals (LMCs) connect the main cerebral arteries and provide alternative pathways for blood flow during ischaemic stroke. This is beneficial for reducing infarct size and reperfusion success after treatment. However, a better understanding of how LMCs affect blood flow distribution is indispensable to improve therapeutic strategies. Here, we present a novel in silico approach that incorporates case-specific in vivo data into a computational model to simulate blood flow in large semi-realistic microvascular networks from two different mouse strains, characterised by having many and almost no LMCs between middle and anterior cerebral artery (MCA, ACA) territories. This framework is unique because our simulations are directly aligned with in vivo data. Moreover, it allows us to analyse perfusion characteristics quantitatively across all vessel types and for networks with no, few and many LMCs. We show that the occlusion of the MCA directly caused a redistribution of blood that was characterised by increased flow in LMCs. Interestingly, the improved perfusion of MCA-sided microvessels after dilating LMCs came at the cost of a reduced blood supply in other brain areas. This effect was enhanced in regions close to the watershed line and when the number of LMCs was increased. Additional dilations of surface and penetrating arteries after stroke improved perfusion across the entire vasculature and partially recovered flow in the obstructed region, especially in networks with many LMCs, which further underlines the role of LMCs during stroke.
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