Evidence map›Paper›PMID 37870648›Full record

ArticleMolecular imaging and biology2024

Toward a Nanoencapsulated EPR Imaging Agent for Clinical Use.

Rhia M Martin, Samantha Diaz, Martin Poncelet, Benoit Driesschaert, Eugene Barth, Mrignayani Kotecha, Boris Epel, Gareth R Eaton, Joshua R Biller

Open access · greenAbstract read
In one paragraph

Article in Molecular imaging and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. What Is the Information Content of EPR Oximetry?Advances in experimental medicine and biology · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Rhia M MartinTDA Research Inc., Golden, CO, 80403, USA.
Samantha DiazTDA Research Inc., Golden, CO, 80403, USA.
Martin PonceletDepartment of Pharmaceutical Sciences, School of Pharmacy & In-Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, 26506, USA.ORCID 0000-0002-2787-8142
Benoit DriesschaertDepartment of Pharmaceutical Sciences, School of Pharmacy & In-Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, 26506, USA.ORCID 0000-0002-1402-413X
Eugene BarthDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, 60637, USA.
Mrignayani KotechaOxygen Measurement Core, O2M Technologies, Chicago, IL, 60612, USA.ORCID 0000-0003-2264-0247
Boris EpelDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, 60637, USA.
Gareth R EatonDepartment of Chemistry, University of Denver, Denver, CO, 80210, USA.ORCID 0000-0001-7429-8469
Joshua R BillerTDA Research Inc., Golden, CO, 80403, USA. jbiller@tda.com.ORCID 0000-0002-3690-0313
TDA Research (United States) · USUniversity of Chicago · USWest Virginia University · USUniversity of Denver · US

Funding

FY20 SBIR PHASE 1 TOPIC #400 - TDA RADI-SENSE: ENCAPSULATED NANOPARTICLE OXYGEN IMAGING AGENTS FOR RADIOTHERAPY GUIDANCE75N91020C00032 · NCI · TDA RESEARCH, INC. · PI BILLER, JOSHUA · 2020 to 2020
$400k
NCI NIH HHS 75N91010C00032NCI NIH HHS 75N91020C00032NIEHS NIH HHS 27300C0032
6 · The paper itself

Abstract

purposeProgress toward developing a novel radiocontrast agent for determining pO PROCEDURES: The imaging agent is based on a nanoscaffold of aluminum hydroxide (boehmite) with sizes from 100 to 200 nm, paramagnetic probe molecule, and encapsulation with a gas permeable, thin (10-20 nm) polymer layer to separate the imaging agent and body environment while still allowing O

resultsSide-by-side in vivo imaging comparisons made in a mouse model made between RADI-Sense and free paramagnetic probe (OX-071) showed oxygen sensitivity is retained and RADI-Sense can create 3D pO

Indexed as

OxygenAnimalsContrast MediaElectron Spin Resonance SpectroscopyHumansMiceNanoparticlesNeoplasmsContrast MediaOxygenElectron paramagnetic resonance (EPR)EncapsulatedEPR imagingImaging agentpO2Radiotherapy guidanceRADI-Sense

Identifiers

PMID37870648
PMCPMC11035482
OpenAlexW4387865769

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.