ArticleClinical research in cardiology : official journal of the German Cardiac Society2025
Impact of right ventricular-to-pulmonary artery coupling on remodeling and outcome in patients undergoing transcatheter edge-to-edge mitral valve repair.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Right Ventricular-to-Pulmonary Artery Uncoupling Following Transcatheter Edge-to-Edge Repair in Ventricular Functional Mitral Regurgitation.JACC. Asia · 2026Article
- RV-PA Uncoupling: Understanding the Continuum of a Failing Heart.JACC. Asia · 2026Article
- Prognostic value of the TAPSE/PASP-ratio in patients with severe mitral regurgitation undergoing transcatheter edge-to-edge mitral valve repair.BMC cardiovascular disorders · 2026Article
- Echocardiographic and invasive RV-PA coupling predict mortality after edge-to-edge repair for degenerative mitral regurgitation, while pulmonary artery pulsatility index does not: a single-center observational study.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Beyond multivalvular disease: imaging-guided diagnosis and management of combined functional mitral and tricuspid regurgitation.European heart journal. Imaging methods and practice · 2025Article
- Right ventricular dysfunction in structural tricuspid interventions.European heart journal. Imaging methods and practice · 2025Review
- Impact of Right Ventricular to Pulmonary Artery Coupling on Survival Following Indirect Mitral Annuloplasty.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
- To clip or not to clip? A review of precise risk assessment in the contemporary era of transcatheter edge-to-edge mitral and tricuspid valve repair.Frontiers in cardiovascular medicine · 2025Review
- Right ventricular to pulmonary arterial coupling as a predictor of survival in patients undergoing mitral valve surgery for mitral regurgitation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024Article
- Mitral Transcatheter Edge-to-Edge Repair and Clinical Value of Novel Echocardiographic Biomarkers: A Hypothesis-Generating Study.Biomedicines · 2024Article
- Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart disease.Frontiers in cardiovascular medicine · 2024Review
- Effect of Right Ventricular Dysfunction on Biventricular Remodeling after Successful Mitral Transcatheter Edge-to-edge Repair in Patients with Severe Mitral Regurgitation. An Echocardiographic Analysis after 1 Year of Repair.Journal of cardiovascular echographyArticle
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17 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRight ventricular-to-pulmonary artery (RV-PA) coupling has recently been shown to be associated with outcome in valvular heart disease. However, longitudinal data on RV dysfunction and reverse cardiac remodeling in patients following transcatheter edge-to-edge mitral valve repair (M-TEER) are scarce.
methodsConsecutive patients with primary as well as secondary mitral regurgitation (MR) were prospectively enrolled and had comprehensive echocardiographic and invasive hemodynamic assessment at baseline. Kaplan-Meier estimates and multivariable Cox-regression analyses were performed, using a composite endpoint of heart failure hospitalization and death.
resultsBetween April 2018 and January 2021, 156 patients (median 78 y/o, 55% female, EuroSCORE II: 6.9%) underwent M-TEER. On presentation, 64% showed impaired RV-PA coupling defined as tricuspid annular plane systolic excursion to pulmonary artery systolic pressure (TAPSE/PASP) ratio < 0.36. Event-free survival rates at 2 years were significantly lower among patients with impaired coupling (57 vs. 82%, p < 0.001), both in patients with primary (64 vs. 91%, p = 0.009) and secondary MR (54 vs. 76%, p = 0.026). On multivariable Cox-regression analyses adjusted for baseline, imaging, hemodynamic, and procedural data, TAPSE/PASP ratio < 0.36 was independently associated with outcome (adj.HR 2.74, 95% CI 1.17-6.43, p = 0.021). At 1-year follow-up, RV-PA coupling improved (TAPSE: ∆ + 3 mm, PASP: ∆ - 10 mmHg, p for both < 0.001), alongside with a reduction in tricuspid regurgitation (TR) severity (grade ≥ II: 77-54%, p < 0.001).
conclusionsTAPSE/PASP ratio was associated with outcome in patients undergoing M-TEER for primary as well as secondary MR. RV-PA coupling, alongside with TR severity, improved after M-TEER and might thus provide prognostic information in addition to established markers of poor outcome.
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