Evidence map›Paper›PMID 37870614›Full record

ArticleCurrent microbiology2023

Antimicrobial and Antibiofilm Activities of Copper(II)-1,10-phenanthroline-5,6-pione Against Commensal Bacteria and Fungi Responsible for Vaginal Microbiota Dysbiosis.

Graziela V Rigo, Fernanda G Cardoso, Michael Devereux, Malachy McCann, Alexandre J Macedo, André L S Santos, Tiana Tasca

Abstract read
PubMed Publisher
In one paragraph

Article in Current microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Graziela V RigoFaculdade de Farmácia and Centro de Biotecnologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
Fernanda G CardosoFaculdade de Farmácia and Centro de Biotecnologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
Michael DevereuxThe Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, Dublin Institute of Technology, Dublin, Ireland.
Malachy McCannChemistry Department, Maynooth University, National University of Ireland, Maynooth, Ireland.
Alexandre J MacedoFaculdade de Farmácia and Centro de Biotecnologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
André L S SantosLaboratório de Estudos Avançados de Microrganismos Emergentes E Resistentes, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Tiana TascaFaculdade de Farmácia and Centro de Biotecnologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil. tiana.tasca@ufrgs.br.ORCID http://orcid.org/0000-0002-8334-5105

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 309764/2021-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior financial code - 001Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 21/2551-0000128-3
6 · The paper itself

Abstract

The disbalance of vaginal eubiotic microbiota can lead to overgrowth of Candida species and bacteria responsible for aerobic vaginitis, activating inflammatory pathways. The presence of Trichomonas vaginalis, a sexually transmitted protozoan pathogen, can be a predisposing factor for disordering the growth of bacterial/fungal pathogenic species due to the increase in pH and reduction of eubiotic microbiota. Herein, we evaluated the effects of the potent trichomonacidal compound, copper(II)-1,10-phenanthroline-5,6-dione (Cu-phendione), against pathogens responsible for candidiasis and aerobic vaginitis. Cu-phendione showed antimicrobial activity against Candida albicans, non-albicans Candida species (C. glabrata, C. krusei, C. parapsilosis, and C. tropicalis) and Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus, Enterococcus faecalis, and Streptococcus agalactiae) bacteria. Moreover, Cu-phendione was able to interfere with the fungal biofilm formation. These results highlight the antimicrobial potential of Cu-phendione against bacterial and fungal strains of vaginitis-causing infectious agents.

Indexed as

Anti-Infective AgentsMicrobiotaPoriferaVaginitisAnimalsBacteriaBiofilmsCandidaCandida glabrataCopperDysbiosisFemaleHumansPhenanthrolines1,10-phenanthrolineAnti-Infective AgentsCopperPhenanthrolines

Identifiers

PMID37870614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.