Evidence map›Paper›PMID 37870582›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2024

Beneficial action of cinnamic acid against ovarian cancer via network pharmacology analysis and the pharmacological activity assessment.

Rong Fan, Zining Liang, Qing Wang, Sizhe Chen, Shiting Huang, Jiansu Liu, Rui Huang, Jie Chen, Feilan Zhao, Wei Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Rong Fan *School of Basic Medical Sciences, Guangxi Traditional Chinese Medical University, No. 179 Mingxiu East Road, Nanning, 530001, China.
Zining Liang *School of Pharmacy, Guangxi Traditional Chinese Medical University, Nanning, 530001, China.
Qing Wang *School of Basic Medical Sciences, Guangxi Traditional Chinese Medical University, No. 179 Mingxiu East Road, Nanning, 530001, China.
Sizhe ChenFirst Clinical Medical College, Guangxi Traditional Chinese Medical University, No. 89-9 Dongge Road, Nanning, 530023, China.
Shiting HuangFirst Clinical Medical College, Guangxi Traditional Chinese Medical University, No. 89-9 Dongge Road, Nanning, 530023, China.
Jiansu LiuFirst Clinical Medical College, Guangxi Traditional Chinese Medical University, No. 89-9 Dongge Road, Nanning, 530023, China.
Rui HuangFirst Clinical Medical College, Guangxi Traditional Chinese Medical University, No. 89-9 Dongge Road, Nanning, 530023, China.
Jie ChenFirst Clinical Medical College, Guangxi Traditional Chinese Medical University, No. 89-9 Dongge Road, Nanning, 530023, China.
Feilan ZhaoSchool of Basic Medical Sciences, Guangxi Traditional Chinese Medical University, No. 179 Mingxiu East Road, Nanning, 530001, China. feilanzhao0503@163.com.
Wei HuangFirst Clinical Medical College, Guangxi Traditional Chinese Medical University, No. 89-9 Dongge Road, Nanning, 530023, China. jinzhuan6@sina.com.
Guangxi University of Chinese Medicine · CN

Funding

National Natural Science Foundation of China Grant No. 81660429Natural Science Foundation of Guangxi Province Grant No. 2020GXNSFAA259043
6 · The paper itself

Abstract

Naturally occurring cinnamic acid (CA) shows the beneficial potential in the suppression of ovarian cancer (OC). Currently, the in-depth molecular mechanisms of CA to suppress OC are still undescribed entirely. Thus, our research used the preclinical methodology through network pharmacology approach and pharmacological evaluation in vitro to unshroud the anti-OC targets and mechanisms of CA. Our data primarily identified 202 CA targets and 495 OC targets, and additional 45 shared targets in CA and OC were screened as presented in interaction network map. All 11 core targets in CA against OC were identified completely. The enrichment analysis of core targets revealed the biological functions and molecular mechanisms of CA against OC in details, including metabolic recombination and immune microenvironment regulation. Additionally, pharmacological evaluation data in vitro suggested that CA inhibited human OC cell proliferation in the time- and dose-dependent manners. In conclusion, CA can exert antineoplastic effects against OC effectively, and the pharmacological functions may directly actualize through a multi-target and multi-pathway avenue for suppressing OC.

Indexed as

Cell ProliferationCinnamatesNetwork PharmacologyOvarian NeoplasmsAntineoplastic AgentsCell Line, TumorFemaleHumansAntineoplastic AgentsCinnamatescinnamic acidBioinformaticsCinnamic acidMechanismsOvarian cancerPharmacological activity

Identifiers

PMID37870582
OpenAlexW4387866463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.