Evidence map›Paper›PMID 37870491›Full record

ArticleRenal failure2023

Upregulation of the protein kinase Lyn is associated with renal injury in type 2 diabetes patients.

Juan Chen, Lingfeng Peng, Jian Sun, Jishi Liu, Ling Chu, Bin Yi, Ming Gui, Hao Zhang, Juan Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Juan ChenDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China and Clinical Research Center for Critical Kidney Disease in Hunan Province.ORCID 0009-0007-5563-9900
Lingfeng PengDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China and Clinical Research Center for Critical Kidney Disease in Hunan Province.
Jian SunDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China and Clinical Research Center for Critical Kidney Disease in Hunan Province.
Jishi LiuDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China and Clinical Research Center for Critical Kidney Disease in Hunan Province.
Ling ChuDepartment of pathology, The Third Xiangya Hospital, Central South University, Changsha, China.
Bin YiDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China and Clinical Research Center for Critical Kidney Disease in Hunan Province.
Ming GuiDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China and Clinical Research Center for Critical Kidney Disease in Hunan Province.
Hao ZhangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China and Clinical Research Center for Critical Kidney Disease in Hunan Province.ORCID 0000-0002-7742-7948
Juan TangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China and Clinical Research Center for Critical Kidney Disease in Hunan Province.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of inflammation in the pathogenesis of type 2 diabetes mellitus (T2DM) is well established. Lyn, a member of the nonreceptor protein tyrosine kinase Src family, has been reported to modulate inflammatory signaling pathways.

methodsLyn expression was assessed in kidney biopsies of 11 patients with diabetic kidney disease (DKD) and in kidney tissues of streptozotocin (STZ)-induced DKD mice. 102 recruited T2DM patients were divided into three groups: normoalbuminuria, microalbuminuria and macroalbuminuria. Twenty-one healthy volunteers were recruited as a control group. Clinical data, blood and urine samples of all individuals were collected for analysis.

resultsLyn expression was augmented in the kidneys of DKD patients and STZ-induced diabetic mice. Compared with control and normoalbuminuria groups, both mRNA and protein expression of Lyn in peripheral blood mononuclear cells (PBMCs) in the macroalbuminuria group were significantly increased (

conclusionLyn levels in PBMCs exhibited a positive correlation with the severity of albuminuria, renal tubular damage, and inflammatory responses. Hence, Lyn may be a compelling candidate for predicting albuminuria levels in diabetes.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Diabetic NephropathiesAlbuminuriaAnimalsBiomarkersHumansKidneyLeukocytes, MononuclearMiceProtein KinasesUp-RegulationBiomarkersProtein Kinasesalbuminuriadiabetic kidney diseaseinflammationProtein kinase lyntype 2 diabetes mellitus

Identifiers

PMID37870491
PMCPMC11001359
OpenAlexW4387866314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.