ArticleNucleic acids research2024
M2OR: a database of olfactory receptor-odorant pairs for understanding the molecular mechanisms of olfaction.
Article in Nucleic acids research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Odor Thresholds in Flavor Science: A Data-Driven Review From Mechanisms to Applications.Comprehensive reviews in food science and food safety · 2026Review
- A clinical and mechanistic study on traditional Chinese medicine herbs used in olfactory training.Chinese medicine · 2026Article
- Low rank adaptation of chemical foundation models generates effective odorant representations.bioRxiv : the preprint server for biology · 2026Article
- What makes a scent trigger a memory? A cognitive decomposition of odor-evoked retrieval.iScience · 2026Article
- Physiopathology of nasal and ecnomotopic olfactory receptors: focus on molecular pathways and potential pharmacological modulation.Frontiers in pharmacology · 2026Review
- Extra-nasal odorant receptors: molecular mechanisms and therapeutic implications.Frontiers in physiology · 2026Review
- Optimizing Odorants for Olfactory Training Based on Olfactory Receptor-Ligand Pair Analysis.The Laryngoscope · 2026Article
- Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion.Molecular therapy. Nucleic acids · 2025Article
- Synergistic Integration of Laser Oxidation and Long Short-Term Memory for Advanced Odor Classification in Next-Generation Artificial Olfactory Systems.ACS sensors · 2025Article
- Property-driven localization and characterization in deep molecular representations.Scientific reports · 2025Article
- Olfactory receptors and human diseases.Cell and tissue research · 2025Review
- Article
- The chordata olfactory receptor database.Protein & cell · 2025Article
- Deep Learning for Odor Prediction on Aroma-Chemical Blends.ACS omega · 2025Article
- Lineage-Specific Class-A GPCR Dynamics Reflect Diverse Chemosensory Adaptations in Lophotrochozoa.Molecular biology and evolution · 2025Article
- Olfactory Receptor Responses to Pure Odorants in Drosophila melanogaster.The European journal of neuroscience · 2025Article
- MORE-Q, a dataset for molecular olfactorial receptor engineering by quantum mechanics.Scientific data · 2025Article
- Olfactory GPCRs through the lens of structural bioinformatics.Chemical senses · 2025Review
- Conserved pattern-based classification of human odorant receptor multigene family.Scientific reports · 2024Article
- Role of Ectopic Olfactory Receptors in the Regulation of the Cardiovascular-Kidney-Metabolic Axis.Life (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Mammalian sense of smell is triggered by interaction between odorant molecules and a class of proteins, called olfactory receptors (ORs). These receptors, expressed at the surface of olfactory sensory neurons, encode myriad of distinct odors via a sophisticated activation pattern. However, determining the molecular recognition spectrum of ORs remains a major challenge. The Molecule to Olfactory Receptor database (M2OR, https://m2or.chemsensim.fr/) provides curated data that allows an easy exploration of the current state of the research on OR-molecule interaction. We have gathered a database of 75,050 bioassay experiments for 51 395 distinct OR-molecule pairs. Drawn from published literature and public databases, M2OR contains information about OR responses to molecules and their mixtures, receptor sequences and experimental details. Users can obtain information on the activity of a chosen molecule or a group of molecules, or search for agonists for a specific OR or a group of ORs. Advanced search allows for fine-grained queries using various metadata such as species or experimental assay system, and the database can be queried by multiple inputs via a batch search. Finally, for a given search query, users can access and download a curated aggregation of the experimental data into a binarized combinatorial code of olfaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.