Evidence map›Paper›PMID 37869960›Full record

ArticleObesity (Silver Spring, Md.)2024

Impact of housing temperature on adipose tissue HDAC9 expression and adipogenic differentiation in high fat-fed mice.

Samah Ahmadieh, Brandee Goo, Abdalrahman Zarzour, David Kim, Hong Shi, Praneet Veerapaneni, Ronnie Chouhaita, Nicole K H Yiew, Carla Dominguez Gonzalez, Akash Chakravartty and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 1 institution in 1 country.

Samah AhmadiehDepartment of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Brandee GooVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.ORCID 0000-0002-9994-6706
Abdalrahman ZarzourDepartment of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
David KimVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.ORCID 0000-0001-6896-6950
Hong ShiDepartment of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Praneet VeerapaneniVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Ronnie ChouhaitaVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Nicole K H YiewVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Carla Dominguez GonzalezVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Akash ChakravarttyVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
James PennoyerVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Nazeera HassanVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Tyler W BensonVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Mourad OgbiVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
David J FultonVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Richard LeeDepartment of Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Robert D RiceDepartment of Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Lisa R HiltonDepartment of Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Yun LeiDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Xin-Yun LuDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Weiqin ChenDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.ORCID 0000-0002-3894-5953
Ha Won KimDepartment of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Neal L WeintraubDepartment of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Augusta University · US

Funding

Novel Role of Bscl2 in Cardiac Substrate Metabolism and FunctionR01HL132182 · NHLBI · AUGUSTA UNIVERSITY · PI Weiqin Chen · 2016 to 2026
$4.1M
The Adipocyte PPARgama/Adiponectin Axis and Alzheimer's DiseaseRF1AG062166 · NIA · AUGUSTA UNIVERSITY · PI LU, XIN-YUN · 2019 to 2019
$3.5M
Neuronal HDAC9, Synaptic Plasticity and Alzheimer's DiseaseR01AG076235 · NIA · AUGUSTA UNIVERSITY · PI Xin-Yun Lu, Neal L Weintraub · 2022 to 2026
$2.8M
Epigenetic regulation of HDAC9 in obesity and atherosclerosisR01HL126949 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2016 to 2019
$1.8M
HDAC9, Aging and Alzheimer's DiseaseR56AG064895 · NIA · AUGUSTA UNIVERSITY · PI LU, XIN-YUN, WEINTRAUB, NEAL L · 2019 to 2020
$1.5M
Novel Posttranslational Modifications in Adipose BiologyR01DK135657 · NIDDK · AUGUSTA UNIVERSITY · PI Weiqin Chen · 2024 to 2026
$1.3M
Role of Histone Deacetylase 9 (HDAC9) in adipose tissue aging: mitochondrial function, oxidative stress and senescenceF30AG074640 · NIA · AUGUSTA UNIVERSITY · PI GOO, BRANDEE · 2022 to 2024
$158k
NHLBI NIH HHS R01 HL126949NHLBI NIH HHS R01 HL132182NIA NIH HHS AG076235NIA NIH HHS F30 AG074640NIA NIH HHS R01 AG076235NIA NIH HHS R56 AG064895NIA NIH HHS RF1 AG062166NIDDK NIH HHS R01 DK135657
6 · The paper itself

Abstract

objectiveImpaired adipogenic differentiation exacerbates metabolic disease in obesity. This study reported that high-fat diet (HFD)-fed mice housed at thermoneutrality exhibited impaired adipogenic differentiation, attributed to increased expression of histone deacetylase 9 (HDAC9). However, the impact of HFD on adipogenic differentiation is reportedly variable, possibly reflecting divergent environmental conditions such as housing temperature.

methodsC57BL/6J (wild-type [WT]) mice were housed at either thermoneutral (28-30°C) or ambient (20-22°C) temperature and fed HFD or chow diet (CD) for 12 weeks. For acute exposure experiments, WT or transient receptor potential cation channel subfamily M member 8 (TRPM8) knockout mice housed under thermoneutrality were acutely exposed to ambient temperature for 6 to 24 h.

resultsWT mice fed HFD and housed at thermoneutrality, compared with ambient temperature, gained more weight despite reduced food intake. They likewise exhibited increased inguinal adipose tissue HDAC9 expression and reduced adipogenic differentiation in vitro and in vivo compared with CD-fed mice. Conversely, HFD-fed mice housed at ambient temperature exhibited minimal change in adipose HDAC9 expression or adipogenic differentiation. Acute exposure of WT mice to ambient temperature reduced adipose HDAC9 expression independent of sympathetic β-adrenergic signaling via a TRPM8-dependent mechanism.

conclusionsAdipose HDAC9 expression is temperature sensitive, regulating adipogenic differentiation in HFD-fed mice housed under thermoneutrality.

Indexed as

Adipose TissueHousingAnimalsDiet, High-FatHistone DeacetylasesMiceMice, Inbred C57BLMice, KnockoutObesityRepressor ProteinsTemperatureHdac9 protein, mouseHistone DeacetylasesRepressor Proteins

Identifiers

PMID37869960
PMCPMC10840750
OpenAlexW4387865319

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.