ArticleObesity (Silver Spring, Md.)2024
Cord blood DNA methylation of immune and lipid metabolism genes is associated with maternal triglycerides and child adiposity.
Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 16 citations in OpenAlex.
- Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Association of atherogenic index of plasma with gestational diabetes mellitus and birth weight outcomes, and the mediating role of blood glucose.Journal of diabetes investigation · 2026Article
- Mitochondrial signatures of infant mesenchymal stem cells predict child adiposity: The Healthy Start Study.Research square · 2026Article
- Maternal BMI associations with cord blood DNA methylation and mid-childhood adiposity.Clinical epigenetics · 2026Observational
- Altered Lipid Profile and Oxidative Stress During Pregnancy: Impact on the Fetus and Risk of Metabolic Disorders in Adulthood.International journal of molecular sciences · 2026Review
- Umbilical cord blood: a comprehensive review of protective and restorative properties in clinical applications - a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Insulin levels at 18-20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood.Clinical epigenetics · 2025Article
- Maternal allostatic load in pregnancy is prospectively associated with child adiposity and metabolic function across infancy and early childhood.Psychoneuroendocrinology · 2025Article
- New Frontiers: Umbilical Cord Mesenchymal Stem Cells Uncover Developmental Roots and Biological Underpinnings of Obesity Susceptibility.Current obesity reports · 2025Review
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- Tracing the Lipid Fingerprints of Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Newborn adiposity is associated with cord blood DNA methylation at IGF1R and KLF7.Obesity (Silver Spring, Md.) · 2024Article
- Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity.JCI insight · 2024Article
- Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring.International journal of molecular sciences · 2024Review
- Differentially methylated regions interrogated for metastable epialleles associate with offspring adiposity.Epigenomics · 2024Article
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Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveFetal exposures may impact offspring epigenetic signatures and adiposity. The authors hypothesized that maternal metabolic traits associate with cord blood DNA methylation, which, in turn, associates with child adiposity.
methodsFasting serum was obtained in 588 pregnant women (27-34 weeks' gestation), and insulin, glucose, high-density lipoprotein cholesterol, triglycerides, and free fatty acids were measured. Cord blood DNA methylation and child adiposity were measured at birth, 4-6 months, and 4-6 years. The association of maternal metabolic traits with DNA methylation (429,246 CpGs) for differentially methylated probes (DMPs) and regions (DMRs) was tested. The association of the first principal component of each DMR with child adiposity was tested, and mediation analysis was performed.
resultsMaternal triglycerides were associated with the most DMPs and DMRs of all traits tested (261 and 198, respectively, false discovery rate < 0.05). DMRs were near genes involved in immune function and lipid metabolism. Triglyceride-associated CpGs were associated with child adiposity at 4-6 months (32 CpGs) and 4-6 years (2 CpGs). One, near CD226, was observed at both timepoints, mediating 10% and 22% of the relationship between maternal triglycerides and child adiposity at 4-6 months and 4-6 years, respectively.
conclusionsDNA methylation may play a role in the association of maternal triglycerides and child adiposity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.