Evidence map›Paper›PMID 37869578›Full record

ArticleBrain communications2023

Fast ripples reflect increased excitability that primes epileptiform spikes.

Shennan A Weiss, Itzhak Fried, Jerome Engel, Michael R Sperling, Robert K S Wong, Yuval Nir, Richard J Staba

Abstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Epileptogenicity alters intrahippocampal ripple propagation.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Shennan A WeissDepartment of Neurology, State University of New York Downstate, Brooklyn, NY 11203, USA.
Itzhak FriedDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Jerome EngelDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Michael R SperlingDepartments of Neurology and Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Robert K S WongDepartment of Physiology and Pharmacology, State University of New York Downstate, Brooklyn, NY 11203, USA.
Yuval NirDepartment of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID https://orcid.org/0000-0002-5433-6349
Richard J StabaDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0003-2285-5627

Funding

IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSR01NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JEROME NONE ENGEL, Richard Staba · 1994 to 2026
$7.5M
Reducing or obviating the need for chronic intracranial electroencephalogram telemetry for epilepsy surgery patients by utilizing inter-ictal HFO rates: A study of diagnostic accuracyK23NS094633 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI WEISS, SHENNAN A · 2017 to 2018
$335k
NINDS NIH HHS K23 NS094633NINDS NIH HHS R01 NS033310
6 · The paper itself

Abstract

The neuronal circuit disturbances that drive inter-ictal and ictal epileptiform discharges remain elusive. Using a combination of extra-operative macro-electrode and micro-electrode inter-ictal recordings in six pre-surgical patients during non-rapid eye movement sleep, we found that, exclusively in the seizure onset zone, fast ripples (200-600 Hz), but not ripples (80-200 Hz), frequently occur <300 ms before an inter-ictal intra-cranial EEG spike with a probability exceeding chance (bootstrapping,

Indexed as

epileptiform spikefast ripplehigh-frequency oscillationneuronripple

Identifiers

PMID37869578
PMCPMC10587774

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.