Evidence map›Paper›PMID 37869576›Full record

ArticleBrain communications2023

Anterior cingulate sulcation is associated with onset and survival in frontotemporal dementia.

Luke Harper, Sterre de Boer, Olof Lindberg, Jimmy Lätt, Nicholas Cullen, Lyles Clark, David Irwin, Lauren Massimo, Murray Grossman, Oskar Hansson and 3 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Variable Presence of an Evolutionarily New Brain Structure Is Related to Trait Impulsivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
  2. Survival rates in frontotemporal dementia and Alzheimer's disease.Neurodegenerative disease management · 2025
    Article
  3. Article
  4. Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Luke HarperClinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden.
Sterre de BoerAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam 1081 HZ, The Netherlands.
Olof LindbergDivision of Clinical Geriatrics, Karolinska Institute, Stockholm 17165, Sweden.
Jimmy LättCentre for Medical Imaging and Physiology, Skane University Hospital, Lund 22242, Sweden.
Nicholas CullenClinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden.
Lyles ClarkPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA 19104, USA.
David IrwinPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0002-5599-5098
Lauren MassimoPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA 19104, USA.
Murray GrossmanPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA 19104, USA.
Oskar HanssonClinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden.ORCID https://orcid.org/0000-0001-8467-7286
Yolande PijnenburgAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam 1081 HZ, The Netherlands.
Corey T McMillanPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA 19104, USA.
Alexander F SantilloClinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden.ORCID https://orcid.org/0000-0001-9717-0820
University of Pennsylvania · USLund University · SEAmsterdam Neuroscience · NLKarolinska Institutet · SESkåne University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frontotemporal dementia is the second most common form of early onset dementia (<65 years). Despite this, there are few known disease-modifying factors. The anterior cingulate is a focal point of pathology in behavioural variant frontotemporal dementia. Sulcation of the anterior cingulate is denoted by the presence of a paracingulate sulcus, a tertiary sulcus developing, where present during the third gestational trimester and remaining stable throughout life. This study aims to examine the impact of right paracingulate sulcal presence on the expression and prognosis of behavioural variant frontotemporal dementia. This retrospective analysis drew its population from two clinical samples recruited from memory clinics at university hospitals in the USA and The Netherlands. Individuals with sporadic behavioural variant frontotemporal dementia were enrolled between 2000 and 2022 and followed up for an average of 7.71 years. T

Indexed as

brain reservecingulatefrontotemporal dementiaparacingulatesulcation

Identifiers

PMID37869576
PMCPMC10586312
OpenAlexW4387446158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.