Evidence map›Paper›PMID 37869166›Full record

ArticleFrontiers in medicine2023

Impact of autologous platelet-rich plasma therapy vs. hyaluronic acid on synovial fluid biomarkers in knee osteoarthritis: a randomized controlled clinical trial.

Tianshu Li, Yuefang Li, Wanyue Li, Xu Wang, Qixin Ding, Jiahuan Gao, Ying Zhang, Weisheng Zhuang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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  17. Effects of hyaluronic acid on skin at the cellular level: a systematic review.Revista da Associacao Medica Brasileira (1992) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Tianshu LiDepartment of Rehabilitation Medicine, People's Hospital of Henan University, The First People's Hospital of Zhengzhou, Zhengzhou, Henan, China.
Yuefang LiDepartment of Rehabilitation Medicine, People's Hospital of Henan University, The First People's Hospital of Zhengzhou, Zhengzhou, Henan, China.
Wanyue LiDepartment of Rehabilitation, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Xu WangSchool of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Qixin DingSchool of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Jiahuan GaoDepartment of Rehabilitation Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Ying ZhangDepartment of Rehabilitation Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Weisheng ZhuangDepartment of Rehabilitation Medicine, People's Hospital of Henan University, The First People's Hospital of Zhengzhou, Zhengzhou, Henan, China.
Zhengzhou People's Hospital · CNFirst Affiliated Hospital of Henan University · CNZhengzhou University · CNFirst Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Observe the effects of platelet-rich plasma (PRP) therapy on inflammatory cytokines in the synovial fluid of the knee joint of patients with KOA, and explore the effects of PRP intra-articular injection on the inflammation of the knee joint environment and the possible mechanism of action. Methods: Seventy patients were randomized to undergo three blinded weekly intra-articular injections of PRP or hyaluronic acid (HA). The concentrations of inflammatory cytokines, including interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, IL-8, IL-17A, IL-17F, IL-4, IL-5, and IL-10, in the synovial fluid were evaluated before the intervention and 1 month after the third injection. The Western Ontario and McMaster University (WOMAC) and visual analog scale (VAS) scores were used to assess pain and functional status of the knee joints in both groups before the intervention, immediately post-intervention, and 1, 3, 6, and 12 months after the intervention. Results: Baseline characteristics were similar in both groups with no statistical difference. The IL-6, IL-1β, TNF-α, IL-17A, and IL-10 levels in the synovial fluid of the observation group decreased significantly after, vs. before, the intervention ( Conclusion: Platelet plasma therapy can reduce the concentrations of inflammatory cytokines IL-6, IL-1β, TNF-α, IL-17A, and IL-10 in the synovial fluid of KOA patients, reduce the expression levels of IL-8, IL-17F, and IL-4, clear the pro-inflammatory factors, improve the inflammatory environment of the affected knee joint, and alleviate pain caused by inflammation. Thus, alleviating pain and improving knee function in patients with KOA.

Indexed as

articular cavity injectionbiomarkersinflammatory cytokinesknee osteoarthritisplatelet-rich plasma

Identifiers

PMID37869166
PMCPMC10585111
OpenAlexW4387375660

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.