Evidence map›Paper›PMID 37869077›Full record

ArticleFrontiers in oncology2023

Germline landscape of

Richa Sharma, Ninad Oak, Wenan Chen, Rose Gogal, Martin Kirschner, Fabian Beier, Michael J Schnieders, Maria Spies, Kim E Nichols, Marcin Wlodarski

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. The canonical RPA complex interacts with Est3 to regulate yeast telomerase activity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Richa SharmaDepartment of Hematology, St. Jude Children´s Research Hospital, Memphis, TN, United States.
Ninad OakDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States.
Wenan ChenCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, United States.
Rose GogalDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Martin KirschnerDepartment of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Fabian BeierDepartment of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Michael J SchniedersDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Maria SpiesDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Kim E NicholsDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States.
Marcin WlodarskiDepartment of Hematology, St. Jude Children´s Research Hospital, Memphis, TN, United States.
St. Jude Children's Research Hospital · USUniversity of Iowa · USRWTH Aachen University · DE

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Optimizing Genetic Testing for Deafness for Clinical DiagnosticsR01DC012049 · NIDCD · UNIVERSITY OF IOWA · PI TERRY A BRAUN, Thomas L. Casavant · 2011 to 2026
$8.7M
Assembly and Dynamics of Molecular Machines in Genome MaintenanceR35GM131704 · NIGMS · UNIVERSITY OF IOWA · PI Maria Spies · 2019 to 2026
$3.9M
Consequences of gain-of-function RPA1 mutations on telomere function and hematopoiesisK08DK134873 · NIDDK · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Richa Sharma · 2022 to 2026
$835k
NCI NIH HHS P30 CA086862NIDCD NIH HHS R01 DC012049NIDDK NIH HHS K08 DK134873NIGMS NIH HHS R35 GM131704
6 · The paper itself

Abstract

Replication Protein A (RPA) is single-strand DNA binding protein that plays a key role in the replication and repair of DNA. RPA is a heterotrimer made of 3 subunits - RPA1, RPA2, and RPA3. Germline pathogenic variants affecting

Indexed as

cancergermline mutationRPA1RPA2RPA3

Identifiers

PMID37869077
PMCPMC10588448
OpenAlexW4387402700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.