Evidence map›Paper›PMID 37868978›Full record

ArticleFrontiers in immunology2023

Macrophage regulation of the "second brain": CD163 intestinal macrophages interact with inhibitory interneurons to regulate colonic motility - evidence from the

Jackson L K Yip, Soniya Xavier, Gayathri K Balasuriya, Elisa L Hill-Yardin, Sarah J Spencer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  2. Review
  3. Enteric nervous system as a therapeutic target in gastrointestinal disorders.World journal of gastrointestinal pharmacology and therapeutics · 2025
    Article
  4. Purinergic P2YPurinergic signalling · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Jackson L K YipSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Soniya XavierSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Gayathri K BalasuriyaSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Elisa L Hill-YardinSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Sarah J SpencerSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
RMIT University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal macrophages are well-studied for their conventional roles in the immune response against pathogens and protecting the gut from chronic inflammation. However, these macrophages may also have additional functional roles in gastrointestinal motility under typical conditions. This is likely to occur via both direct and indirect influences on gastrointestinal motility through interaction with myenteric neurons that contribute to the gut-brain axis, but this mechanism is yet to be properly characterised. The CX3CR1 chemokine receptor is expressed in the majority of intestinal macrophages, so we used a conditional knockout

Indexed as

InterneuronsMacrophagesAnimalsBrainCD163 AntigenCX3C Chemokine Receptor 1Heparin-binding EGF-like Growth FactorRatsCD163 AntigenCX3C Chemokine Receptor 1CX3CR1 protein, ratHbegf protein, ratHeparin-binding EGF-like Growth Factorcolonic motilitygastrointestinalmacrophagesmyenteric plexusnitric oxide

Identifiers

PMID37868978
PMCPMC10585175
OpenAlexW4387365467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.