Evidence map›Paper›PMID 37868743›Full record

ReviewBehavioural neurology2023

Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review.

Kuldeep Singh, Bharat Bhushan, Dilip Kumar Chanchal, Satish Kumar Sharma, Ketki Rani, Manoj Kumar Yadav, Prateek Porwal, Shivendra Kumar, Ashwani Sharma, Tarun Virmani and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Behavioural neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  8. Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions.Liver international : official journal of the International Association for the Study of the Liver · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Kuldeep SinghDepartment of Pharmacology, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, India.ORCID https://orcid.org/0000-0001-8772-8157
Bharat BhushanDepartment of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.
Dilip Kumar ChanchalDepartment of Pharmacognosy, Glocal School of Pharmacy, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, India.
Satish Kumar SharmaDepartment of Pharmacognosy, Glocal School of Pharmacy, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, India.
Ketki RaniDepartment of Chemistry, SGT College of Pharmacy, SGT University, Gurugram, Haryana, India.
Manoj Kumar YadavDepartment of Pharmacology, Dr. Bhimrao Ambedkar University, Chhalesar Campus, Agra, Uttar Pradesh, India.
Prateek PorwalDepartment of Pharmacognosy, Glocal School of Pharmacy, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, India.
Shivendra KumarDepartment of Pharmacology, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, India.
Ashwani SharmaSchool of Pharmaceutical Sciences, MVN University, 121105, Palwal, Haryana, India.ORCID https://orcid.org/0000-0001-9399-0856
Tarun VirmaniSchool of Pharmaceutical Sciences, MVN University, 121105, Palwal, Haryana, India.ORCID https://orcid.org/0000-0002-1615-5213
Girish KumarSchool of Pharmaceutical Sciences, MVN University, 121105, Palwal, Haryana, India.ORCID https://orcid.org/0000-0002-2917-3277
Abdullah Al NomanSchool of Pharmacy, BRAC University, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0001-7627-4970
Glocal University · INMVN University · INRajiv Gandhi University of Health Sciences · INBRAC University · BDGLA University · INShree Guru Gobind Singh Tricentenary University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabidiol (CBD), derived from Cannabis sativa, has gained remarkable attention for its potential therapeutic applications. This thorough analysis explores the increasing significance of CBD in treating neurological conditions including epilepsy, multiple sclerosis, Parkinson's disease, and Alzheimer's disease, which present major healthcare concerns on a worldwide scale. Despite the lack of available therapies, CBD has been shown to possess a variety of pharmacological effects in preclinical and clinical studies, making it an intriguing competitor. This review brings together the most recent findings on the endocannabinoid and neurotransmitter systems, as well as anti-inflammatory pathways, that underlie CBD's modes of action. Synthesized efficacy and safety assessments for a range of neurological illnesses are included, covering human trials, in vitro studies, and animal models. The investigation includes how CBD could protect neurons, control neuroinflammation, fend off oxidative stress, and manage neuronal excitability. This study emphasizes existing clinical studies and future possibilities in CBD research, addressing research issues such as regulatory complications and contradicting results, and advocates for further investigation of therapeutic efficacy and ideal dose methodologies. By emphasizing CBD's potential to improve patient well-being, this investigation presents a revised viewpoint on its suitability as a therapeutic intervention for neurological illnesses.

Indexed as

Alzheimer DiseaseCannabidiolEpilepsyAnimalsHumansCannabidiol

Identifiers

PMID37868743
PMCPMC10586905
OpenAlexW4387568568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.