Evidence map›Paper›PMID 37868702›Full record

ArticleJournal of porphyrins and phthalocyanines

Interactions of metronidazole and chloramphenicol with myoglobin: Crystal structure of a Mb-acetamide product.

Samantha M Powell, Kiana Y Prather, Nancy Nguyen, Leonard M Thomas, George B Richter-Addo

Open access · greenAbstract read
In one paragraph

Article in Journal of porphyrins and phthalocyanines. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Samantha M PowellPrice Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, and Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, U.S.A. 73019.
Kiana Y PratherPrice Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, and Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, U.S.A. 73019.
Nancy NguyenPrice Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, and Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, U.S.A. 73019.
Leonard M ThomasPrice Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, and Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, U.S.A. 73019.
George B Richter-AddoPrice Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, and Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, U.S.A. 73019.
Oklahoma City University · USUniversity of Oklahoma · USPacific Northwest National Laboratory · US

Funding

Structure-Function Studies of MsvR, a Methanogen-Specific Transcriptional RegulaP20GM103640 · NIGMS · UNIVERSITY OF OKLAHOMA · PI THOMAS, LEONARD M · 2012 to 2021
$20.4M
NIGMS NIH HHS P20 GM103640
6 · The paper itself

Abstract

Nitroorganics present a general concern for a safe environment due to their health hazards. However, some nitroorganics such as metronidazole (Mtz) and chloramphenicol (CAM) also possess medicinal value. Mtz and CAM can undergo reductive bioactivation presumably via their nitroso derivatives. We show, using UV-vis spectroscopy, that sperm whale myoglobin (swMb) and its distal pocket mutants retaining H-bonding capacity react with Mtz in the presence of dithionite to generate products with spectra suggestive of the Fe-bound nitroso (Fe-RNO; λ

Indexed as

acetamidechloramphenicolHememetronidazolemyoglobinnitrosoX-ray structure

Identifiers

PMID37868702
PMCPMC10588810
OpenAlexW4323361433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.