Evidence map›Paper›PMID 37868626›Full record

ArticleiScience2023

Statistical modeling of extracellular vesicle cargo to predict clinical trial outcomes for hypoplastic left heart syndrome.

Jessica R Hoffman, Hyun-Ji Park, Sruti Bheri, Manu O Platt, Joshua M Hare, Sunjay Kaushal, Judith L Bettencourt, Dejian Lai, Timothy C Slesnick, William T Mahle and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03406884 (Autologous Cardiac Stem Cell Injection in Patients With Hypoplastic Left Heart Syndrome), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03406884 phase1completednot on this map

Autologous Cardiac Stem Cell Injection in Patients With Hypoplastic Left Heart Syndrome: An Open Label Pilot Study.

TypeinterventionalSponsorJoshua M HareRan2019 to 2024Enrolled25ConditionsHypoplastic Left Heart SyndromeArmsc-kit+ cells
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jessica R HoffmanWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine & Georgia Institute of Technology, Atlanta, GA 30322, USA.
Hyun-Ji ParkWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine & Georgia Institute of Technology, Atlanta, GA 30322, USA.
Sruti BheriWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine & Georgia Institute of Technology, Atlanta, GA 30322, USA.
Manu O PlattWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine & Georgia Institute of Technology, Atlanta, GA 30322, USA.
Joshua M HareMiller School of Medicine, University of Miami, Miami, FL 33136, USA.
Sunjay KaushalDepartments of Surgery and Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Judith L BettencourtCoordinating Center for Clinical Trials, Department of Biostatistics and Data Science, University of Texas Health Science Center School of Public Health, Houston, TX 77030, USA.
Dejian LaiCoordinating Center for Clinical Trials, Department of Biostatistics and Data Science, University of Texas Health Science Center School of Public Health, Houston, TX 77030, USA.
Timothy C SlesnickDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
William T MahleDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Michael E DavisWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine & Georgia Institute of Technology, Atlanta, GA 30322, USA.

Funding

Graduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1M
Predictive and systems modeling of exosome cargoR01HL145644 · NHLBI · EMORY UNIVERSITY · PI DAVIS, MICHAEL E · 2019 to 2022
$3.1M
Computational modeling of stem cells predicts clinical trial outcomes for hypoplastic left heart syndromeF31HL154725 · NHLBI · EMORY UNIVERSITY · PI HOFFMAN, JESSICA REGGAN · 2020 to 2021
$87k
NHLBI NIH HHS F31 HL154725NHLBI NIH HHS R01 HL145644NIGMS NIH HHS T32 GM008602
6 · The paper itself

Abstract

Cardiac-derived c-kit+ progenitor cells (CPCs) are under investigation in the CHILD phase I clinical trial (NCT03406884) for the treatment of hypoplastic left heart syndrome (HLHS). The therapeutic efficacy of CPCs can be attributed to the release of extracellular vesicles (EVs). To understand sources of cell therapy variability we took a machine learning approach: combining bulk CPC-derived EV (CPC-EV) RNA sequencing and cardiac-relevant

Indexed as

Drug delivery systemMedicineStatistical physics

Identifiers

PMID37868626
PMCPMC10589850

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.