ArticleCell genomics2023
Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology.
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Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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58citing papers in PubMed, 1 pooled it
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmacogenomic markers associated with drug-induced QT prolongation: a systematic review.PharmacogenomicsPooled it
- All of Us diversity and scale yield context-dependent improvements in polygenic prediction.Nature genetics · 2026Article
- Genetic architectures of brain-related traits are shaped by strong selective constraints.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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- Genome-wide tandem repeat expansions modify schizophrenia risk in the presence of a 22q11.2 deletion.Molecular psychiatry · 2026Article
- TLS-Tractor: A transfer learning framework for incorporating summary-statistics into local ancestry-aware GWAS in admixed populations.medRxiv : the preprint server for health sciences · 2026Article
- Cross-ancestry polygenic risk scores enhance Alzheimer's disease risk prediction in multiethnic cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Extending genome-wide association studies to admixed cohorts with high degrees of relatedness.Nature genetics · 2026Article
- Investigations on transferability of polygenic risk scores depending on demography and dominance coefficients.HGG advances · 2026Article
- DiscoDivas: Leveraging genetic-ancestry continuum information to interpolate PRS for admixed populations.American journal of human genetics · 2026Article
- Improving Polygenic Risk Prediction for Atherosclerotic Cardiovascular Disease in East Asian Populations.JACC. Asia · 2026Review
- Bridging ancestry gaps in genomic risk prediction with tabular foundation models.Bioinformatics (Oxford, England) · 2026Article
- Bridging Ancestry Gaps in Genomic Risk Prediction with Tabular Foundation Models.bioRxiv : the preprint server for biology · 2026Article
- Multi-omics insights into uric acid metabolism in cardiometabolic disease: from genetics to metabolomics.Biomedical journal · 2026Review
- Ancestral diversity in complex disease genetics: from discovery to translation.Nature reviews. Genetics · 2026Review
- Phenome-derived polygenic scores and social determinants jointly shape context-dependent disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Genetic architectures of brain-related traits are shaped by strong selective constraints.bioRxiv : the preprint server for biology · 2026Article
- Polygenic scores capture genetic modification of the adiposity-cardiometabolic risk factor relationship.Cell genomics · 2026Article
- The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder.Behavior genetics · 2026Article
- A novel simulation tool for low-coverage whole-genome sequencing using multivariate Gaussian mixture models.BMC bioinformatics · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Ying WangAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Masahiro KanaiAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Taotao TanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Mireille KamarizaSociety of Fellows, Harvard University, Cambridge, MA 02138, USA.
Kristin TsuoAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Kai YuanAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Wei ZhouAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
BioBank Japan Project
Hailiang HuangAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Patrick TurleyDepartment of Economics, and Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
Elizabeth G AtkinsonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Alicia R MartinAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Funding
Enabling improved applicability and transferability of polygenic scores across populationsU01HG011719 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI Alicia Martin · 2021 to 2026
$5.5M2/7 Psychiatric Genomics Consortium: Finding Actionable VariationU01MH109539 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2016 to 2020
$4.7MIdentification and characterization of inflammatory bowel disease causal variantsR01DK129364 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Hailiang Huang · 2022 to 2026
$3.4MEmpowering gene discovery and accelerating clinical translation for diverse admixed populationsR01HG012869 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Elizabeth Grace Atkinson · 2023 to 2026
$3.1MGenome-wide analysis of late-onset Alzheimer's disease using intergenerational, multi-trait, and cross-ancestry dataR00AG062787 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TURLEY, PATRICK ANSEL · 2021 to 2023
$747kGeneralizing polygenic risk prediction methods across populations for insights into psychiatric diseaseR00MH117229 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MARTIN, ALICIA · 2020 to 2022
$724kA framework enabling the genomic analysis of psychiatric traits across admixed populations.K01MH121659 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ATKINSON, ELIZABETH GRACE · 2019 to 2022
$719kGenetics and gene regulation in the inflammatory bowel diseasesK01DK114379 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, HAILIANG · 2017 to 2021
$632kNHGRI NIH HHS R01 HG012869NHGRI NIH HHS U01 HG011719NIA NIH HHS R00 AG062787NIDDK NIH HHS K01 DK114379NIDDK NIH HHS R01 DK129364NIMH NIH HHS K01 MH121659NIMH NIH HHS R00 MH117229NIMH NIH HHS U01 MH109539
Abstract
Polygenic risk scores (PRSs) developed from multi-ancestry genome-wide association studies (GWASs), PRS
Indexed as
genetic architecturegenome-wide association studiesmulti-ancestrypolygenic risk scores
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.