Evidence map›Paper›PMID 37867522›Full record

ArticleFrontiers in endocrinology2023

Multiple endocrine neoplasia type 1 with Zollinger-Ellison syndrome: clinicopathological analysis of a Japanese family with focus on menin immunohistochemistry.

Noriko Kimura, Yasuji Hirata, Nozomu Iwashiro, Hiroshi Kijima, Shinobu Takayasu, Satoshi Yamagata, Satoru Sakihara, Shinya Uchino, Masanori Ohara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Noriko KimuraDepartment of Clinical Research, National Hospital Organization Hakodate Hospital, Hakodate, Hokkaido, Japan.
Yasuji HirataDepartment of Hematology and Oncology, National Hospital Organization Hakodate Hospital, Hakodate, Hokkaido, Japan.
Nozomu IwashiroDepartment of Surgery, National Hospital Organization Hakodate Hospital, Hakodate, Hokkaido, Japan.
Hiroshi KijimaDepartment of Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
Shinobu TakayasuDepartment of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine and Hospital, Hirosaki, Aomori, Japan.
Satoshi YamagataDepartment of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine and Hospital, Hirosaki, Aomori, Japan.
Satoru SakiharaDepartment of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine and Hospital, Hirosaki, Aomori, Japan.
Shinya UchinoDepartment of Endocrine Surgery, Noguchi Thyroid Clinic and Hospital Foundation, Beppu, Oita, Japan.
Masanori OharaDepartment of Surgery, National Hospital Organization Hakodate Hospital, Hakodate, Hokkaido, Japan.
Hakodate National Hospital · JPHirosaki University · JPColumbia University Irving Medical Center · USNational Hospital Organization · JPNoguchi Thyroid Clinic and Hospital Foundation · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the occurrence of multiple epithelial neuroendocrine tumors (NETs) and non-NETs in various organs. Patients and methods: All family members had a germline alteration in exon 10, c.1714-1715 del TC of Results: Two patients died of pulmonary NET G2. One patient who underwent pancreaticoduodenectomy was cured of ZES; however, the two other patients who did not undergo pancreaticoduodenectomy suffered persistent ZES despite treatment with octreotide. Menin IHC revealed varying NET intensities, ranging from positive to negative stains. Conclusion: Pancreaticoduodenectomy is the most effective treatment for ZES. Long-term follow-up is essential for pulmonary NET G2 owing to the risk of distant metastasis and/or multiplicity. Moreover, the variability of menin IHC in MEN1-related tumors may indicate the pattern of tumor formation rather than the diagnostic utility of menin in MEN1.

Indexed as

Multiple Endocrine Neoplasia Type 1Neuroendocrine TumorsZollinger-Ellison SyndromeEast Asian PeopleHumansImmunohistochemistryProto-Oncogene ProteinsTranscription FactorsMEN1 protein, humanProto-Oncogene ProteinsTranscription Factorsimmunohistochemistrymeninmetastasismultiple endocrine neoplasia type 1neuroendocrine tumorprognosispulmonary atypical carcinoidZollinger-Ellison syndrome

Identifiers

PMID37867522
PMCPMC10588651
OpenAlexW4387408117

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.