Evidence map›Paper›PMID 37866952›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2023

[YKL-40 Promotes the Expression of Inflammatory Factors in Type Ⅱ Alveolar Epithelial Cell Model of A549 Cell Line].

Zhiyong Miao, Jingjing Ran, Dachao Mou, Shasha Wu, Yanqiong Chen, Cong Li, Yuehong Chen, Min Yang, Qibing Xie

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zhiyong MiaoLaboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China.
Jingjing RanCore Facility of West China Hospital, Sichuan University, Chengdu 610041, China.
Dachao MouLaboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China.
Shasha WuLaboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China.
Yanqiong ChenLaboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China.
Cong LiCore Facility of West China Hospital, Sichuan University, Chengdu 610041, China.
Yuehong ChenDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Min YangDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Qibing XieDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan University · CNWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: YKL-40, also known as chitinase-3-like-1 (CHI3L1), is a human cartilage glycoprotein-39, with its N-terminus consisting of tyrosine (Y), lysine (K), and leucine (L), hence the name YKL-40. In this study, we explored whether YKL-40 could promote the expression of inflammatory factors in type Ⅱ alveolar epithelial cells. Methods: A549 cells were cultured Results: RT-qPCR results showed that IL-1β could up-regulate YKL-40 protein transcription level compared with that of the control group and the difference was statistically significant ( Conclusion: YKL-40 can promote the expression and secretion of IL-6, IL-8, and other acute inflammatory factors in A549 cell line, a type Ⅱ alveolar epithelial cell model, thus aggravating the inflammatory response. Targeted inhibition of YKL-40 expression may effectively inhibit inflammatory response.

Indexed as

Alveolar Epithelial CellsTumor Necrosis Factor-alphaA549 CellsChitinase-3-Like Protein 1HumansInterferon-gammaInterleukin-6Interleukin-8CHI3L1 protein, humanChitinase-3-Like Protein 1Interferon-gammaInterleukin-6Interleukin-8Tumor Necrosis Factor-alphaInflammatory responseSmall interfering RNAType Ⅱ alveolar epithelial cellYKL-40

Identifiers

PMID37866952
PMCPMC10579078
OpenAlexW4387866232

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.