Evidence map›Paper›PMID 37866852›Full record

ReviewClinics in perinatology2023

Anemia, Iron Supplementation, and the Brain.

Tate Gisslen, Raghavendra Rao, Michael K Georgieff

Open access · greenAbstract readReview
In one paragraph

Review in Clinics in perinatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 9 citations in OpenAlex.

  1. Pregnancy diet based on ancestral patterns increases growth in subcortical fetal brain regions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Trial
  2. Assessment of iron sufficiency in premature infants treated with darbepoetin using conventional and novel erythrocyte metrics.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  3. Article
  4. Twin anemia polycythemia sequence and the risk of iron deficiency in donors and iron overload in recipients.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Using the refineR algorithm to generate indirect reference intervals for newborn infants for the parameters "Micro-R" and "HYPO-He".Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tate GisslenDivision of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Academic Office Building, 2450 Riverside Avenue, SAO-401, Minneapolis, MN 55454, USA. Electronic address: tgisslen@umn.edu.
Raghavendra RaoDivision of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Academic Office Building, 2450 Riverside Avenue, SAO-401, Minneapolis, MN 55454, USA.
Michael K GeorgieffDivision of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Academic Office Building, 2450 Riverside Avenue, SAO-401, Minneapolis, MN 55454, USA.
University of Minnesota Medical Center · US

Funding

THE RoLE OF NEONATAL ANEMIA IN LEARNING AND MEMORYP01HL046925 · NHLBI · UNIVERSITY OF IOWA · PI SOLA-VISNER, MARTHA C. · 1992 to 2022
$34.3M
Newborn Iron DeficiencyR01HD094809 · NICHD · UNIVERSITY OF MINNESOTA · PI Michael K. Georgieff · 2018 to 2026
$3.6M
Detection and Correction of Iron Deficiency Induced Abnormal Brain MetabolismR01HD089989 · NICHD · UNIVERSITY OF MINNESOTA · PI COE, CHRISTOPHER L, GEORGIEFF, MICHAEL K. · 2017 to 2021
$2.7M
Altered postnatal microglial function following fetal inflammation and its effect on long-term neurodevelopment of neonatal miceK08HD099246 · NICHD · UNIVERSITY OF MINNESOTA · PI GISSLEN, TATE A. · 2019 to 2023
$679k
NHLBI NIH HHS P01 HL046925NICHD NIH HHS K08 HD099246NICHD NIH HHS L40 HD081595NICHD NIH HHS R01 HD089989NICHD NIH HHS R01 HD094809
6 · The paper itself

Abstract

The developing brain is particularly vulnerable to extrinsic environmental events such as anemia and iron deficiency during periods of rapid development. Studies of infants with postnatal iron deficiency and iron deficiency anemia clearly demonstrated negative effects on short-term and long-term brain development and function. Randomized interventional trials studied erythropoiesis-stimulating agents and hemoglobin-based red blood cell transfusion thresholds to determine how they affect preterm infant neurodevelopment. Studies of red blood cell transfusion components are limited in preterm neonates. A biomarker strategy measuring brain iron status and health in the preanemic period is desirable to evaluate treatment options and brain response.

Indexed as

Anemia, NeonatalErythropoietinIron DeficienciesBrainDietary SupplementsHumansInfantInfant, Low Birth WeightInfant, NewbornInfant, PrematureIronErythropoietinIronAnemiaBiomarkersBrainErythropoietinIron deficiencyNeurodevelopmentPrematureTransfusion

Identifiers

PMID37866852
PMCPMC10590989
OpenAlexW4386333356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.