Evidence map›Paper›PMID 37866793›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2024

Modification of Association of Cystatin C With Kidney and Cardiovascular Outcomes by Obesity.

Debbie C Chen, Rebecca Scherzer, Joachim H Ix, Holly J Kramer, Deidra C Crews, Girish Nadkarni, Orlando Gutierrez, Alexander L Bullen, Titilayo Ilori, Pranav S Garimella and 2 more

Abstract read
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Risk factor obesity: treatment standard.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Review
  3. Article
  4. One Year at AJKD: A Perspective From the 2023-2024 Editorial Interns.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Debbie C ChenDivision of Nephrology, Department of Medicine, University of California at San Francisco, San Francisco; Kidney Health Research Collaborative, San Francisco VA Medical Center & University of California, San Francisco; Genentech, Inc., South San Francisco.
Rebecca ScherzerKidney Health Research Collaborative, San Francisco VA Medical Center & University of California, San Francisco; Department of Medicine, San Francisco VA Medical Center, San Francisco.
Joachim H IxDivision of Nephrology-Hypertension, University of California at San Diego, San Diego; Nephrology Section, Veterans Affairs San Diego Healthcare System, San Dieg, California.
Holly J KramerDivision of Nephrology and Hypertension, Loyola University Medical Center, Maywood, Illinois.
Deidra C CrewsDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Girish NadkarniDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Division of Data Driven and Digital Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Mount Sinai Clinical Intelligence Cente, Icahn School of Medicine at Mount Sinai, New York, New York.
Orlando GutierrezDivision of Nephrology, UAB Heersink School of Medicine, Birmingham, Alabama.
Alexander L BullenDivision of Nephrology-Hypertension, University of California at San Diego, San Diego; Nephrology Section, Veterans Affairs San Diego Healthcare System, San Dieg, California.
Titilayo IloriSection of Nephrology, Department of Medicine, Boston Medical Center, School of Medicine, Boston University, Boston, Massachusetts.
Pranav S GarimellaDivision of Nephrology-Hypertension, University of California at San Diego, San Diego.
Michael G ShlipakDepartment Epidemiology and Biostatistics, University of California at San Francisco, San Francisco; Kidney Health Research Collaborative, San Francisco VA Medical Center & University of California, San Francisco; Department of Medicine, San Francisco VA Medical Center, San Francisco.
Michelle M EstrellaDivision of Nephrology, Department of Medicine, University of California at San Francisco, San Francisco; Kidney Health Research Collaborative, San Francisco VA Medical Center & University of California, San Francisco; Division of Nephrology, San Francisco VA Medical Center, San Francisco; Department of Medicine, San Francisco VA Medical Center, San Francisco. Electronic address: michelle.estrella@ucsf.edu.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
The Role of Dietary Nutrients in Chronic Kidney Disease Progression and Apolipoprotein L1 NephropathyK23DK119542 · NIDDK · BOSTON MEDICAL CENTER · PI ILORI, TITILAYO OMOLARA · 2020 to 2024
$928k
NIDDK NIH HHS K23 DK119542NIH HHS S10 OD026880NIH HHS S10 OD030463NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

RATIONALE &

objectiveCystatin C-based estimated glomerular filtration rate (eGFR STUDY

designCohort study. SETTING &

participants27,249 US adults in the Reasons for Geographic and Racial Differences in Stroke Study. PREDICTORS: eGFR OUTCOME: All-cause mortality, kidney failure, incident atherosclerotic cardiovascular disease (ASCVD), and incident heart failure (HF). ANALYTICAL APPROACH: Multivariable Cox and Fine-Gray models with multiplicative interaction terms were constructed to investigate whether waist circumference quartiles or BMI categories modified associations of eGFR

resultsParticipants had a mean age of 65 years; 54% were women, 41% were Black, and 21% had an eGFR LIMITATIONS: Included only Black and White persons in the United States.

conclusionObesity did not modify the association of eGFR PLAIN-LANGUAGE SUMMARY: Cystatin C is increasingly used in clinical practice to estimate kidney function, and cystatin C-based eGFR (eGFR

Indexed as

AtherosclerosisCystatin CRenal InsufficiencyRenal Insufficiency, ChronicAdultAgedCohort StudiesCreatinineFemaleGlomerular Filtration RateHumansKidneyMaleObesityUnited StatesCreatinineCST3 protein, humanCystatin CCardiovascular diseasechronic kidney diseasecystatin Cestimated glomerular filtration rateobesity

Identifiers

PMID37866793
PMCPMC10960714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.