Evidence map›Paper›PMID 37866719›Full record

ArticleMucosal immunology2024

The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling.

M Elliott Williams, Felica P Hardnett, Anandi N Sheth, Alexander N Wein, Zheng-Rong Tiger Li, Jessica Radzio-Basu, Chuong Dinh, Lisa B Haddad, Elizabeth M B Collins, Igho Ofotokun and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. T-Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

M Elliott WilliamsDepartment of Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Felica P HardnettDivision of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Anandi N ShethDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine and Grady Health System, Atlanta, GA, USA.
Alexander N WeinDepartment of Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Zheng-Rong Tiger LiDepartment of Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Jessica Radzio-BasuDivision of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Chuong DinhDivision of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Lisa B HaddadDepartment of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
Elizabeth M B CollinsDepartment of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
Igho OfotokunDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine and Grady Health System, Atlanta, GA, USA.
Rustom AntiaDepartment of Biology, Emory University, Atlanta, GA, USA.
Christopher D ScharerDepartment of Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA, USA.
J Gerardo Garcia-LermaDivision of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jacob E KohlmeierDepartment of Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Alison Swaims-KohlmeierDepartment of Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA, USA; Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA; Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: askohlm@emory.edu.
Emory University · USCenters for Disease Control and Prevention · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Cellular and molecular programming of lung resident T cell memoryR35HL150803 · NHLBI · EMORY UNIVERSITY · PI JACOB E KOHLMEIER · 2020 to 2026
$5.4M
Multiscale modeling of influenza vaccination strategies for optimal T cell immunityU01HL139483 · NHLBI · EMORY UNIVERSITY · PI KOHLMEIER, JACOB E, ZARNITSYNA, VERONIKA I · 2018 to 2022
$3.5M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalKL2TR000455 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$2.9M
Characterization and modulation of mucosal immunity for HIV prevention in womenK23AI114407 · NIAID · EMORY UNIVERSITY · PI SHETH, ANANDI NAYAN · 2014 to 2018
$898k
Impact of progestin contraception on risk of HIV acquisition and transmissionK23HD078153 · NICHD · EMORY UNIVERSITY · PI HADDAD, LISA BLAKE · 2014 to 2018
$704k
NCATS NIH HHS KL2 TR000455NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR002378NCRR NIH HHS UL1 RR025008NHLBI NIH HHS R35 HL150803NHLBI NIH HHS U01 HL139483NIAID NIH HHS K23 AI114407NIAID NIH HHS P30 AI050409NICHD NIH HHS K23 HD078153NIH HHS P51 OD011132
6 · The paper itself

Abstract

Despite their importance for immunity against sexually transmitted infections, the composition of female reproductive tract (FRT) memory T-cell populations in response to changes within the local tissue environment under the regulation of the menstrual cycle remains poorly defined. Here, we show that in humans and pig-tailed macaques, the cycle determines distinct clusters of differentiation 4 T-cell surveillance behaviors by subsets corresponding to migratory memory (T

Indexed as

CD4-Positive T-LymphocytesGenitalia, FemaleMenstrual CycleReceptors, CCR5Signal TransductionCCR5 Receptor AntagonistsCellular MicroenvironmentFemaleHumansImmunologic MemoryMacaca nemestrinaT-Lymphocyte SubsetsCCR5 protein, humanCCR5 Receptor AntagonistsReceptors, CCR5

Identifiers

PMID37866719
PMCPMC10990418
OpenAlexW4387826486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.