Evidence map›Paper›PMID 37866162›Full record

ArticleRedox biology2023

Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H

Giulia Blandino, Mara Fiorani, Barbara Canonico, Rita De Matteis, Andrea Guidarelli, Mariele Montanari, Gloria Buffi, Lucia Coppo, Elias S J Arnér, Orazio Cantoni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Giulia BlandinoDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Mara FioraniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy. Electronic address: mara.fiorani@uniurb.it.
Barbara CanonicoDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Rita De MatteisDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Andrea GuidarelliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Mariele MontanariDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Gloria BuffiDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Lucia CoppoDivision of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Elias S J ArnérDivision of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Department of Selenoprotein Research and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.
Orazio CantoniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
University of Urbino · ITKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term treatment of schizophrenia with clozapine (CLZ), an atypical antipsychotic drug, is associated with an increased incidence of metabolic disorders mediated by poorly understood mechanisms. We herein report that CLZ, while slowing down the morphological changes and lipid accumulation occurring during SW872 cell adipogenesis, also causes an early (day 3) inhibition of the expression/nuclear translocation of CAAT/enhancer-binding protein β and peroxisome proliferator-activated receptor γ. Under the same conditions, CLZ blunts NADPH oxidase-derived reactive oxygen species (ROS) by a dual mechanism involving enzyme inhibition and ROS scavenging. These effects were accompanied by hampered activation of the nuclear factor (erythroid-derived2)-like 2 (Nrf2)-dependent antioxidant responses compared to controls, and by an aggravated formation of mitochondrial superoxide. CLZ failed to exert ROS scavenging activities in the mitochondrial compartment but appeared to actively scavenge cytosolic H

Indexed as

ClozapineLiposarcomaAdipogenesisAnimalsFibroblastsHumansHydrogen PeroxideMiceMitochondriaNADPH OxidasesNF-E2-Related Factor 2Reactive Oxygen SpeciesSuperoxidesClozapineHydrogen PeroxideNADPH OxidasesNF-E2-Related Factor 2Reactive Oxygen SpeciesSuperoxidesAdipocyte differentiationClozapineMitochondrial dysfunctionMitochondrial ROSNADPH oxidase

Identifiers

PMID37866162
PMCPMC10623370
OpenAlexW4387541844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.