Evidence map›Paper›PMID 37865647›Full record

ArticleNature communications2023

Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV

Jose M Ayuso, Mehtab Farooqui, María Virumbrales-Muñoz, Katheryn Denecke, Shujah Rehman, Rebecca Schmitz, Jorge F Guerrero, Cristina Sanchez-de-Diego, Sara Abizanda Campo, Elizabeth M Maly and 8 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Jose M AyusoDepartment of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. ayusodomingu@wisc.edu.ORCID 0000-0002-9414-1845
Mehtab FarooquiDepartment of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
María Virumbrales-MuñozDepartment of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0003-3660-8651
Katheryn DeneckeDepartment of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Shujah RehmanMorgridge Institute for Research, 330 N Orchard street, Madison, WI, USA.ORCID 0000-0001-9527-743X
Rebecca SchmitzThe University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.
Jorge F GuerreroMcArdle Laboratory for Cancer Research, University of Wisconsin, Madison, USA.ORCID 0000-0002-4510-5151
Cristina Sanchez-de-DiegoDepartment of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Sara Abizanda CampoDepartment of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Elizabeth M MalyThe University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.
Matthew H ForsbergDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, USA.
Sheena C KerrDepartment of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Robert StrikerDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, USA.
Nathan M ShererMcArdle Laboratory for Cancer Research, University of Wisconsin, Madison, USA.ORCID 0000-0001-9974-236X
Paul M HarariDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Christian M CapitiniThe University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-2276-6731
Melissa C SkalaThe University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-6320-7637
David J BeebeDepartment of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0002-0415-9006
University of Wisconsin–Madison · USMorgridge Institute for Research · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Visualizing EBV and HCMV DNA Dynamics During InfectionP01CA022443 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F. Lambert · 1985 to 2026
$53.1M
Medical Scientist Training ProgramT32GM144295 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALAN R HAUSER · 2022 to 2026
$9.1M
Radiation response within the tumor microenvironmentR01CA164492 · NCI · UNIVERSITY OF CHICAGO · PI KRON, STEPHEN J. · 2011 to 2015
$4.8M
The Cell Biology of HIV-1 Genome TraffickingR01AI110221 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Nathan M Sherer · 2014 to 2026
$4.4M
Functional optical imaging for rapid, label-free predictions of treatment response and clonal evolution in patient-derived cancer organoidsR01CA272855 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI Dustin A Deming, Melissa Caroline Skala · 2023 to 2026
$3.1M
Label-free imaging of CAR T cell metabolismR01CA278051 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI Christian Capitini, Krishanu Saha · 2023 to 2026
$2.6M
Label-free single-cell imaging for quality control of cardiomyocyte biomanufacturingR01HL165726 · NHLBI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI Sean P Palecek, Melissa Caroline Skala · 2023 to 2026
$2.5M
(PQ7) Quantitative in vivo optical imaging of tumor heterogeneityR01CA205101 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI SKALA, MELISSA CAROLINE · 2016 to 2020
$1.9M
Cellular-level Optical Metabolic Imaging to Predict Drug Response in CancerR01CA185747 · NCI · VANDERBILT UNIVERSITY · PI SKALA, MELISSA CAROLINE · 2014 to 2019
$1.6M
The Dual Reporter Sensor Cell (DRSC) Assay: An Enhanced Tool for Measuring the Viral ReservoirR21AI155008 · NIAID · UNIVERSITY OF KENTUCKY · PI BERRY, SCOTT M, SHERER, NATHAN M · 2020 to 2021
$360k
NCI NIH HHS P01 CA022443NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA164492NCI NIH HHS R01 CA185747NCI NIH HHS R01 CA205101NCI NIH HHS R01 CA272855NCI NIH HHS R01 CA278051NHLBI NIH HHS R01 HL165726NIAID NIH HHS R01 AI110221NIAID NIH HHS R21 AI155008NIGMS NIH HHS T32 GM144295
6 · The paper itself

Abstract

Numerous studies are exploring the use of cell adoptive therapies to treat hematological malignancies as well as solid tumors. However, there are numerous factors that dampen the immune response, including viruses like human immunodeficiency virus. In this study, we leverage human-derived microphysiological models to reverse-engineer the HIV-immune system interaction and evaluate the potential of memory-like natural killer cells for HIV

Indexed as

Head and Neck NeoplasmsHIV InfectionsVirusesHIVHumansImmunotherapyKiller Cells, Natural

Identifiers

PMID37865647
PMCPMC10590421
OpenAlexW4387844683

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.