ArticleCell stem cell2023
TGFB1 induces fetal reprogramming and enhances intestinal regeneration.
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Article in Cell stem cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69citing papers in PubMed
27.6field-weighted citation impact, top 1% of its field
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Who cites it
69 citing papers in PubMed, 88 citations in OpenAlex.
- Extensive genomic diversity in Desulfovibrio reveals species-specific functional traits associated with disease.Nature communications · 2026Article
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- Paneth cell-derived Notch ligands DLL1 and DLL4 are crucial for intestinal crypt base stem cells.bioRxiv : the preprint server for biology · 2026Article
- Helicobacter pylori triggers gastric mucosal remodeling toward a fetal-like transcriptional program via stromal IL-1β signaling.Nature communications · 2026Article
- A spatial and temporal transcriptomic atlas of mouse intestinal regeneration in the jejunum.Nature communications · 2026Article
- TGF‑β1 in cancer: From tumour suppressor to promoter, molecular mechanisms, and precision therapeutic strategies (Review).International journal of oncology · 2026Review
- Amelioration of Acute Oxazolone-Induced Colitis via Oral Administration of EPICERTIN, a Mucosal Healing Biotherapeutic for Inflammatory Bowel Disease.Biomedicines · 2026Article
- Chrono-atlas of cell-type specific daily gene expression rhythms in the regenerating colon.Nature communications · 2026Article
- Dynamic Reprogramming of PDGFRA-Expressing Stromal Cells Facilitates WNT-Driven Transformation by Promoting a Fetal-Like State in the Intestinal Epithelium.Cancer research · 2026Article
- CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β.The Journal of experimental medicine · 2026Article
- Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair.Nature communications · 2026Article
- Kinase inhibitors in organoid media influenceMicrobiology spectrum · 2026Article
- Intestinal stearoyl-CoA desaturase-2 is highly expressed and nutritionally regulated but dispensable for energy balance.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026Article
- ILC3s mediate intestinal immune-epithelial interactions via TGF-β1 activation.Mucosal immunology · 2026Article
- EPICERTIN, an engineered variant of cholera toxin B subunit, promotes survival and a pro-remodeling macrophage phenotype for mucosal healing in colitis.Mucosal immunology · 2026Article
- Intrinsic mechanisms and microenvironmental cues fine-tune plasticity of esophageal progenitors.Nature communications · 2026Article
- M2-like GAMs secreting CSTA drive glioblastoma progression via the ITGB4-TGFB1 feedback axis.Journal of translational medicine · 2026Article
- Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine-Dependent Pro-Inflammatory Immune Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell transcriptomic comparison of the developing human fetal stomach and pluripotent stem cell-derived gastric organoids.Development (Cambridge, England) · 2026Article
- Distinct SOX9 single-molecule dynamics characterize adult differentiation and fetal-like reprogrammed states in intestinal organoids.Stem cell reports · 2026Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 7 institutions in 3 countries.
Lei ChenSchool of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China. Electronic address: leichen@seu.edu.cn.
Xia QiuDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 00854, USA.
Abigail DupreDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 00854, USA.
Oscar Pellon-CardenasDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 00854, USA.
Xiaojiao FanSchool of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Xiaoting XuSchool of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Prateeksha RoutDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 00854, USA.
Katherine D WaltonDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Joseph BurclaffJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, and North Carolina State University, Chapel Hill, NC 27695, USA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Ruolan ZhangSchool of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Wenxin FangSchool of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Rachel OferDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 00854, USA.
Alexandra LogerfoDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 00854, USA.
Kiranmayi VemuriDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 00854, USA.
Sheila BandyopadhyayDepartment of Biological Sciences, Rutgers University-Newark, Newark, NJ 07102, USA.
Jianming WangDepartment of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University-New Brunswick, New Brunswick, NJ 08903, USA.
Gaetan BarbetChild Health Institute of New Jersey, Rutgers University-New Brunswick, New Brunswick, NJ 08901, USA.
Yan WangCenter for Translation Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Nan GaoDepartment of Biological Sciences, Rutgers University-Newark, Newark, NJ 07102, USA.
Ansu O PerekattDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
Wenwei HuDepartment of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University-New Brunswick, New Brunswick, NJ 08903, USA.
Scott T MagnessJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, and North Carolina State University, Chapel Hill, NC 27695, USA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Jason R SpenceDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI 48109, USA.
Michael P VerziDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 00854, USA; Rutgers Cancer Institute of New Jersey, Rutgers University-New Brunswick, New Brunswick, NJ 08903, USA; Rutgers Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, Rutgers University-New Brunswick, New Brunswick, NJ 08901, USA; NIEHS Center for Environmental Exposures and Disease (CEED), Rutgers EOHSI, Piscataway, NJ 08854, USA. Electronic address: verzi@biology.rutgers.edu.
Rutgers, The State University of New Jersey · USSoutheast University · CNUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USChinese Academy of Sciences · CNSoutheast University · BDStevens Institute of Technology · US
Funding
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5MX-RAY STRUCTURE OF RIFM PROTEIN FROM THE BIOSYNTHESIS PATHWAY OF THE ANSAMYCIN AP41RR012408 · NCRR · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MARIUZZA, ROY A · 1998 to 2011
$32.2MPILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5MDEVELOPMENT OF HUMAN INTESTINAL SIMULACRAR01DK109559 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ALLBRITTON, NANCY L., BULTMAN, SCOTT J · 2015 to 2019
$5.2MNiche support of human intestinal stem cellsU01DK103141 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPENCE, JASON · 2014 to 2023
$3.9MRutgers Biotechnology Training ProgramT32GM135141 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ANN M. STOCK, Martin L Yarmush · 2020 to 2026
$3.5MIMSD at Rutgers - New Brunswick (Renewal)T32GM139804 · NIGMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Brian Daniels, JAMES H. MILLONIG · 2021 to 2026
$2.9MPaneth cell heterogeneity in infection and inflammationR01DK132885 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI Nan Gao · 2022 to 2026
$2.4MMechanisms Driving Metabolic Shifts in the Intestinal EpitheliumR01DK126446 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI VERZI, MICHAEL P. · 2021 to 2025
$2.1MResearch Supplements to Promote Diversity in Health-Related ResearchR01DK119198 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI GAO, NAN, KIELA, PAWEL R · 2019 to 2023
$1.9MThe role of leukemia inhibitory factor in colorectal cancerR01CA260838 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Wenwei Hu · 2022 to 2026
$1.9MMechanisms of Hedgehog Regulation of Intestinal Villus MorphogenesisR01DK121166 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WALTON, KATHERINE DEMPSEY · 2019 to 2023
$1.8MNCI NIH HHS P30 CA072720NCI NIH HHS R01 CA260838NCRR NIH HHS P41 RR012408NIDDK NIH HHS F31 DK137596NIDDK NIH HHS P30 DK034987NIDDK NIH HHS R01 DK109559NIDDK NIH HHS R01 DK115806NIDDK NIH HHS R01 DK119198NIDDK NIH HHS R01 DK121166NIDDK NIH HHS R01 DK121915NIDDK NIH HHS R01 DK126446NIDDK NIH HHS R01 DK132885NIDDK NIH HHS R01 DK137806NIDDK NIH HHS U01 DK103141NIGMS NIH HHS T32 GM135141NIGMS NIH HHS T32 GM139804
Abstract
The gut epithelium has a remarkable ability to recover from damage. We employed a combination of high-throughput sequencing approaches, mouse genetics, and murine and human organoids and identified a role for TGFB signaling during intestinal regeneration following injury. At 2 days following irradiation (IR)-induced damage of intestinal crypts, a surge in TGFB1 expression is mediated by monocyte/macrophage cells at the location of damage. The depletion of macrophages or genetic disruption of TGFB signaling significantly impaired the regenerative response. Intestinal regeneration is characterized by the induction of a fetal-like transcriptional signature during repair. In organoid culture, TGFB1 treatment was necessary and sufficient to induce the fetal-like/regenerative state. Mesenchymal cells were also responsive to TGFB1 and enhanced the regenerative response. Mechanistically, pro-regenerative factors, YAP/TEAD and SOX9, are activated in the epithelium exposed to TGFB1. Finally, pre-treatment with TGFB1 enhanced the ability of primary epithelial cultures to engraft into damaged murine colon, suggesting promise for cellular therapy.
Indexed as
Intestinal MucosaIntestinesAnimalsColonHumansMiceOrganoidsSignal TransductionTransforming Growth Factor beta1TGFB1 protein, humanTgfb1 protein, mouseTransforming Growth Factor beta1Clufetal reversionintestinemacrophagemonocyteorganoid transplantationregenerationregenerative medicinerevival stem cellTGFB1
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