ArticleNeuron2023
Excitation creates a distributed pattern of cortical suppression due to varied recurrent input.
Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The Importance of Synchrony in the Neural Control of Movement.bioRxiv : the preprint server for biology · 2026Article
- Neural population dynamics of direct electrical stimulation of neocortex.Cell reports · 2026Article
- Virtual brain and electroencephalography explain the variance of memory alterations in mild cognitive impairment.Alzheimer's research & therapy · 2026Article
- Millimeter-scale selective amplification in the developing visual cortex.bioRxiv : the preprint server for biology · 2026Article
- Neural mechanisms underlying intracortical microstimulation for sensory restoration.Nature biomedical engineering · 2026Review
- Critical scaling of novelty in the cortex.Nature communications · 2026Article
- Neural population dynamics of direct electrical stimulation of neocortex.bioRxiv : the preprint server for biology · 2025Article
- Recurrent circuits encode de novo visual center-surround computations in the mouse superior colliculus.PLoS biology · 2025Article
- Network dynamics underlying activity-timescale differences between cortical regions.bioRxiv : the preprint server for biology · 2025Article
- Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model.bioRxiv : the preprint server for biology · 2025Article
- Recurrent cortical networks encode natural sensory statistics via sequence filtering.bioRxiv : the preprint server for biology · 2025Article
- Touch-evoked traveling waves establish a translaminar spacetime code.Science advances · 2025Article
- Article
- Cellular-resolution optogenetics reveals attenuation-by-suppression in visual cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Local stimulation of pyramidal neurons in deep cortical layers of anesthetized rats enhances cortical visual information processing.Scientific reports · 2024Article
- Single-cell optogenetics reveals attenuation-by-suppression in visual cortical neurons.bioRxiv : the preprint server for biology · 2024Article
- Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex.Journal of neural engineering · 2024Article
- Amplified cortical neural responses as animals learn to use novel activity patterns.Current biology : CB · 2023Article
- Article
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Authors and funding
6 authors.
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Abstract
Dense local, recurrent connections are a major feature of cortical circuits, yet how they affect neurons' responses has been unclear, with some studies reporting weak recurrent effects, some reporting amplification, and others indicating local suppression. Here, we show that optogenetic input to mouse V1 excitatory neurons generates salt-and-pepper patterns of both excitation and suppression. Responses in individual neurons are not strongly predicted by that neuron's direct input. A balanced-state network model reconciles a set of diverse observations: the observed dynamics, suppressed responses, decoupling of input and output, and long tail of excited responses. The model shows recurrent excitatory-excitatory connections are strong and also variable across neurons. Together, these results demonstrate that excitatory recurrent connections can have major effects on cortical computations by shaping and changing neurons' responses to input.
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