Evidence map›Paper›PMID 37864990›Full record

ArticlePregnancy hypertension2023

Src kinase partially mediates cytokine-induced endothelial dysfunction.

Amanda K Mauro, Luca Clemente, Nauman Khurshid, Dinesh M Shah, Jing Zheng, Derek S Boeldt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pregnancy hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Amanda K MauroPerinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin - Madison, School Medicine and Public Health, Madison, WI 53715, USA.
Luca ClementePerinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin - Madison, School Medicine and Public Health, Madison, WI 53715, USA.
Nauman KhurshidPerinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin - Madison, School Medicine and Public Health, Madison, WI 53715, USA; Division of Reproductive Sciences, Department of Obstetrics & Gynecology, University of Wisconsin - Madison, School Medicine and Public Health, Madison, WI 53715, USA.
Dinesh M ShahPerinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin - Madison, School Medicine and Public Health, Madison, WI 53715, USA; Division of Reproductive Sciences, Department of Obstetrics & Gynecology, University of Wisconsin - Madison, School Medicine and Public Health, Madison, WI 53715, USA.
Jing ZhengPerinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin - Madison, School Medicine and Public Health, Madison, WI 53715, USA.
Derek S BoeldtPerinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin - Madison, School Medicine and Public Health, Madison, WI 53715, USA. Electronic address: dsboeldt@wisc.edu.
University of Wisconsin–Madison · US

Funding

Endocrinology-Reproductive Physiology Training GrantT32HD041921 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BIRD, IAN M. · 2004 to 2022
$3.0M
Integrated Program in Endocrinology Translational Postdoctoral Training ProgramT32HD101384 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI IAN M. BIRD, Jon E Levine · 2021 to 2026
$2.0M
High Throughput Strategies for Preeclampsia TherapyR03HD079865 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BOELDT, DEREK S · 2015 to 2016
$152k
NICHD NIH HHS R03 HD079865NICHD NIH HHS T32 HD041921NICHD NIH HHS T32 HD101384
6 · The paper itself

Abstract

objectivesEndothelial dysfunction is known to be a key characteristic of preeclampsia (PE) and can contribute to progression of symptoms and injury to multiple organ systems. Delivery is the only treatment for progression of PE, but development of an endothelial-based therapy for PE presents a promising strategy. Growth factors and cytokines are dysregulated in PE and can impact endothelial function, manifesting changes in Ca STUDY

designFura-2 Ca

main outcome measuresDecreases in HUVEC Ca

resultsWe show that Src inhibition protects Ca

conclusionsThe results of this study suggest cytokine and growth factor-stimulated Src kinase plays a partial role on promoting endothelial dysfunction in HUVECs.

Indexed as

Pre-Eclampsiasrc-Family KinasesCells, CulturedCytokinesFemaleHumansHuman Umbilical Vein Endothelial CellsMitogen-Activated Protein Kinase KinasesPregnancyTumor Necrosis Factor-alphaCytokinesMitogen-Activated Protein Kinase Kinasessrc-Family KinasesTumor Necrosis Factor-alphaCytokineEndothelialGrowth factorHUVECPreeclampsiaSrc kinase

Identifiers

PMID37864990
PMCPMC10873000
OpenAlexW4387768317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.