Evidence map›Paper›PMID 37864794›Full record

ArticleCell reports2023

Lung cDC1 and cDC2 dendritic cells priming naive CD8

Youhui Si, Yihan Wang, Qiaomu Tian, Qiang Wang, Jared M Pollard, Pramod K Srivastava, Aaron P Esser-Kahn, Joel H Collier, Anne I Sperling, Anita S Chong

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  15. Mucosal immunotherapy targeting APC in lung disease.Journal of inflammation (London, England) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Youhui SiNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; Department of Surgery, The University of Chicago, Chicago, IL 60637, USA. Electronic address: youhui@mail.hzau.edu.cn.
Yihan WangDepartment of Surgery, The University of Chicago, Chicago, IL 60637, USA.
Qiaomu TianDepartment of Surgery, The University of Chicago, Chicago, IL 60637, USA.
Qiang WangDepartment of Surgery, The University of Chicago, Chicago, IL 60637, USA.
Jared M PollardDepartment of Surgery, The University of Chicago, Chicago, IL 60637, USA.
Pramod K SrivastavaDepartment of Immunology and Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT 06032, USA.
Aaron P Esser-KahnPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA.
Joel H CollierDepartment of Biomedical Engineering, Duke University, Durham, NC 27710, USA.
Anne I SperlingDepartment of Medicine, Pulmonary and Critical Care, University of Virginia, Charlottesville, VA 22908, USA.
Anita S ChongDepartment of Surgery, The University of Chicago, Chicago, IL 60637, USA. Electronic address: achong@uchicago.edu.
University of Chicago · USDuke University · USHuazhong Agricultural University · CNUniversity of Connecticut · USUniversity of Virginia · US

Funding

Project-003U19AI162310 · NIAID · UNIVERSITY OF CHICAGO · PI Marcelo A. Nobrega · 2021 to 2026
$10.6M
Discovery of adjuvants via novel modulation of innate immune pathways for vaccines against influenza75N93019C00041 · NIAID · UNIVERSITY OF CHICAGO · PI ESSER-KAHN, AARON · 2019 to 2024
$10.0M
Modular Self-Assembled Coatings for BiomaterialsR01EB009701 · NIBIB · UNIVERSITY OF CHICAGO · PI COLLIER, JOEL H · 2009 to 2021
$4.3M
Supramolecular nanofiber vaccinesR01AI118182 · NIAID · UNIVERSITY OF CHICAGO · PI CHONG, ANITA S, COLLIER, JOEL H · 2015 to 2019
$3.1M
NIAID NIH HHS 75N93019C00041NIAID NIH HHS R01 AI118182NIAID NIH HHS U19 AI162310NIBIB NIH HHS R01 EB009701
6 · The paper itself

Abstract

The current paradigm indicates that naive T cells are primed in secondary lymphoid organs. Here, we present evidence that intranasal administration of peptide antigens appended to nanofibers primes naive CD8

Indexed as

CD8-Positive T-LymphocytesDendritic CellsAnimalsCross-PrimingLungLymph NodesMiceBatf3KOCD8+ T cellsCP: Immunologycross-primedendritic cellsintranasallung

Identifiers

PMID37864794
PMCPMC10676754
OpenAlexW4387855408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.