ArticleCell reports2023
Chlorophyll biosynthesis under the control of arginine metabolism.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The structural chemistry and biosynthesis of chlorophylls.RSC chemical biology · 2026Review
- Physiological and Molecular Response Mechanisms ofInternational journal of molecular sciences · 2026Article
- Integrated multi-omics reveals the molecular basis of protein storage in developing oat grains.BMC plant biology · 2025Article
- Unveiling the molecular mechanisms of the stress resilience of High Arctic Klebsormidium flaccidum: a multifaceted study.Plant & cell physiology · 2025Article
- Impact of amino acid supplementation on hydroponic lettuce (Lactuca sativa L.) growth and nutrient content.Scientific reports · 2025Article
- Article
- Metabolomics and quantitative analysis to determine differences in the geographical origins and species of Chinese dragon's blood.Frontiers in plant science · 2024Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In natural environments, photosynthetic organisms adjust their metabolism to cope with the fluctuating availability of combined nitrogen sources, a growth-limiting factor. For acclimation, the dynamic degradation/synthesis of tetrapyrrolic pigments, as well as of the amino acid arginine, is pivotal; however, there has been no evidence that these processes could be functionally coupled. Using co-immunopurification and spectral shift assays, we found that in the cyanobacterium Synechocystis sp. PCC 6803, the arginine metabolism-related ArgD and CphB enzymes form protein complexes with Gun4, an essential protein for chlorophyll biosynthesis. Gun4 binds ArgD with high affinity, and the Gun4-ArgD complex accumulates in cells supplemented with ornithine, a key intermediate of the arginine pathway. Elevated ornithine levels restricted de novo synthesis of tetrapyrroles, which arrested the recovery from nitrogen deficiency. Our data reveal a direct crosstalk between tetrapyrrole biosynthesis and arginine metabolism that highlights the importance of balancing photosynthetic pigment synthesis with nitrogen homeostasis.
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Registered trials
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