Evidence map›Paper›PMID 37864596›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2024

Risk of wrist fracture, estimated by the load-to-strength ratio, declines following sleeve gastrectomy in adolescents and young adults.

Deborah M Mitchell, Vibha Singhal, Supritha Nimmala, Meghan Lauze, Mary L Bouxsein, Madhusmita Misra, Miriam A Bredella

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02557438 (Bone Metabolism in Adolescents Undergoing Bariatric Surgery), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02557438 active not recruitingnot on this map

Bone Metabolism in Adolescents Undergoing Bariatric Surgery

TypeobservationalSponsorMassachusetts General HospitalRan2015 to 2027Enrolled240ConditionsObesity, SurgeryArmsRoux-en-Y Gastric Bypass, Vertical Sleeve Gastrectomy
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Deborah M MitchellDivision of Pediatric Endocrinology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. dmmitchell@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-0364-9107
Vibha SinghalDivision of Pediatric Endocrinology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9729-4433
Supritha NimmalaNeuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4503-2570
Meghan LauzeNeuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Mary L BouxseinEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7027-7414
Madhusmita MisraDivision of Pediatric Endocrinology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9405-2981
Miriam A BredellaDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5482-0440
Harvard University · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2000 to 2019
$31.4M
Bone Metabolism in Adolescents Undergoing Bariatric SurgeryR01DK103946 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BREDELLA, MIRIAM ANTOINETTE, MISRA, MADHUSMITA · 2015 to 2019
$3.2M
Determinants of Beta Cell Function Following Sleeve Gastrectomy in AdolescentsK23DK110419 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SINGHAL, VIBHA · 2016 to 2021
$1.1M
Bone Metabolism in Adolescents UndergoingBariatric SurgeryK24DK109940 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BREDELLA, MIRIAM ANTOINETTE · 2017 to 2021
$970k
XtremeCT II High Resolution Peripheral Computed Tomography DeviceS10OD025248 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BOUXSEIN, MARY L · 2019 to 2019
$445k
NCATS NIH HHS UL1 TR001102NCATS NIH HHS UL1 TR002541NIDDK NIH HHS K23 DK110419NIDDK NIH HHS K24 DK109940NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK103946NIH HHS S10 OD025248
6 · The paper itself

Abstract

To understand whether the bone loss which occurs after vertical sleeve gastrectomy increases the risk of fracture, we used an engineering model to estimate risk in participants before and after surgery. We found that estimated risk decreased 1 year after surgery and remained lower, though had rebounded, at year 2. PURPOSE: Vertical sleeve gastrectomy (VSG) improves metabolic health in young people with obesity but is accompanied by substantial loss of bone mass and estimated bone strength. We thus estimated fracture risk following VSG using the load-to-strength ratio (LSR), which integrates bone strength estimates with the predicted force of a fall.

methodsProspective 2-year study of youth ages 13-24 years with obesity undergoing VSG (n = 24) or lifestyle therapy (n = 34). We performed high-resolution peripheral quantitative computed tomography of the distal radius and microfinite element analysis to estimate bone strength and calculated LSR.

resultsVSG participants lost 26.4 ± 8.1% weight at year 1 (p < 0.001), which was sustained at year 2, while control participants gained weight at year 2 (4.5 ± 8.3%, p = 0.009). The predicted impact force decreased at years 1 and 2 following VSG (p < 0.001) but increased at year 2 among controls (p = 0.011). Estimated bone strength was unchanged at year 1 but decreased (p < 0.001) at year 2 following VSG, while bone strength did not change in controls. At year 1, the LSR decreased among VSG participants (p < 0.001), implying a lower risk of fracture. At year 2, the LSR was lower than baseline (p < 0.001), but higher compared to year 1 (p = 0.001). LSR did not change in the control group.

conclusionsShort-term estimated fracture risk at the radius following VSG decreases. However, ongoing bone loss despite stable weight between years 1 and 2 leads to a concerning rise in estimated fracture risk. Longer follow-up will be critical to evaluate the trajectory of fracture risk. (ClinicalTrials.gov NCT02557438, registered 9/23/2015).

Indexed as

Fractures, BoneWrist FracturesWrist InjuriesAdolescentGastrectomyHumansObesityProspective StudiesWeight LossYoung AdultFractureLoad-to-strength ratioMetabolic and bariatric surgeryObesitySleeve gastrectomy

Identifiers

PMID37864596
PMCPMC12912706
OpenAlexW4387848532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.