Evidence map›Paper›PMID 37864209›Full record

Trial reportEuropean journal of medical research2023

The effect of spinal versus general anaesthesia on perioperative muscle weakness in patients having bilateral total hip arthroplasty: a single center randomized clinical trial.

Sam Van Boxstael, Laurens Peene, Dimitri Dylst, Joris Penders, Admir Hadzic, Ingrid Meex, Kristoff Corten, Dieter Mesotten, Steven Thiessen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03600454 (The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03600454 nacompletednot on this map

The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response

TypeinterventionalSponsorZiekenhuis Oost-LimburgRan2018 to 2019Enrolled50ConditionsMuscle Weakness, Anesthesia, Anesthesia, Local, SurgeryArmsGeneral anesthesia, Spinal anesthesia, General anesthesia and epidural analgesia
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sam Van Boxstael *Critical Care Department, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium. sam.vanboxstael@zol.be.
Laurens Peene *Critical Care Department, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium.
Dimitri DylstCritical Care Department, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium.
Joris PendersLaboratory of Clinical Biology, Ziekenhuis Oost-Limburg, Genk, Belgium.
Admir HadzicCritical Care Department, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium.
Ingrid MeexCritical Care Department, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium.
Kristoff CortenDepartment of Orthopaedic Surgery, Ziekenhuis Oost-Limburg, Genk, Belgium.
Dieter MesottenCritical Care Department, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium.
Steven ThiessenCritical Care Department, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium.
Ziekenhuis Oost-Limburg · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerioperative neuro-endocrine stress response may contribute to acquired muscle weakness. Regional anaesthesia has been reported to improve the outcome of patients having total hip arthroplasty. In this study, it was hypothesized that spinal anaesthesia (SA) decreases the perioperative neuro-endocrine stress response and perioperatively acquired muscle weakness (PAMW), as compared to general anaesthesia (GA).

methodsFifty subjects undergoing bilateral total hip arthroplasty (THA) were randomly allocated to receive a standardized SA (n = 25) or GA (n = 25). Handgrip strength was assessed preoperatively, on the first postoperative day (primary endpoint) and on day 7 and 28. Respiratory muscle strength was measured by maximal inspiratory pressure (MIP). Stress response was assessed by measuring levels of Adrenocorticotropic hormone (ACTH), cortisol and interleukin-6 (IL-6).

resultsHandgrip strength postoperatively (day 1) decreased by 5.4 ± 15.9% in the SA group, versus 15.2 ± 11.7% in the GA group (p = 0.02). The handgrip strength returned to baseline at day 7 and did not differ between groups at day 28. MIP increased postoperatively in patients randomized to SA by 11.7 ± 48.3%, whereas it decreased in GA by 12.2 ± 19.9% (p = 0.04). On day 7, MIP increased in both groups, but more in the SA (49.0 ± 47.8%) than in the GA group (14.2 ± 32.1%) (p = 0.006). Postoperatively, the levels of ACTH, cortisol and IL-6 increased in the GA, but not in the SA group (p < 0.004).

conclusionIn patients having bilateral THA, SA preserved the postoperative respiratory and peripheral muscle strength and attenuated the neuro-endocrine and inflammatory responses.

trial registrationclinicaltrials.gov NCT03600454.

Indexed as

Arthroplasty, Replacement, HipAdrenocorticotropic HormoneAnesthesia, GeneralHand StrengthHumansHydrocortisoneInterleukin-6Muscle WeaknessAdrenocorticotropic HormoneHydrocortisoneInterleukin-6Bilateral total hip arthroplastyGeneral anaesthesiaNeuro-endocrine stress responsePerioperative muscle weaknessSpinal anaesthesia

Identifiers

PMID37864209
PMCPMC10588152
OpenAlexW4387816435

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.