Evidence map›Paper›PMID 37864206›Full record

ArticleCellular & molecular biology letters2023

A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells.

Xiuyan Zhang, Yu Wang, Jinchang Lu, Lun Xiao, Hui Chen, Quanxue Li, Yuan-Yuan Li, Peng Xu, Changgeng Ruan, Haixia Zhou and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular biology letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. A novel regulatory circuit of ATG4B and SESN3 promotes T cell leukemogenesis.Journal of experimental & clinical cancer research : CR · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiuyan ZhangCyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China. zhangxiuyan@suda.edu.cn.
Yu WangCyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
Jinchang LuCyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
Lun XiaoDepartment of Vascular Surgery, The Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, China.
Hui ChenCyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
Quanxue LiShanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China.
Yuan-Yuan LiShanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China.
Peng XuCyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
Changgeng RuanJiangsu Institute of Hematology, NHC Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Haixia ZhouJiangsu Institute of Hematology, NHC Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. zhouhaixia@suda.edu.cn.
Yun ZhaoCyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China. zhaoy@suda.edu.cn.ORCID http://orcid.org/0000-0002-0065-4675
Soochow University · CNNanjing Drum Tower Hospital · CN

Funding

National Natural Science Foundation of China 31371392National Natural Science Foundation of China 81500119Translational Research Grant of NCRCH 2020WSB02Translational Research Grant of NCRCH 2020WSB09Translational Research Grant of NCRCH 2021ZKMB02
6 · The paper itself

Abstract

backgroundZinc finger protein X-linked (ZFX) has been shown to promote the growth of tumor cells, including leukemic cells. However, the role of ZFX in the growth and drug response of chronic myeloid leukemia (CML) stem/progenitor cells remains unclear.

methodsReal-time quantitative PCR (RT-qPCR) and immunofluorescence were used to analyze the expression of ZFX and WNT3 in CML CD34

resultsWe showed that ZFX expression was significantly higher in CML CD34

conclusionThe present study identified a novel ZFX/WNT3 axis that modulates the growth and IM response of CML stem/progenitor cells.

Indexed as

beta CateninLeukemia, Myelogenous, Chronic, BCR-ABL PositiveDrug Resistance, NeoplasmHumansImatinib MesylateNeoplastic Stem CellsSignal TransductionStem CellsWnt3 Proteinbeta CateninImatinib MesylateWnt3 ProteinWNT3 protein, humanCD34+ cellsChronic myeloid leukemiaImatinib mesylateWNT3ZFX

Identifiers

PMID37864206
PMCPMC10589942
OpenAlexW4387808974

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.