ArticleScientific reports2023
Combined ultrasound and photoacoustic C-mode imaging system for skin lesion assessment.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Roadmap for light interaction with biophotonic surfaces and their diverse applications.Journal of biomedical optics · 2026Article
- Ring-segment piezopolymer sensor optimized for cylindrical-wave detection in optical-resolution optoacoustic angiography with extended imaging depth.Biomedical optics express · 2025Article
- In Vivo Differentiation of Cutaneous Melanoma From Benign Nevi With Dual-Modal System of Optical Coherence Tomography and Raman Spectroscopy.Journal of biophotonics · 2025Article
- Diagnostic System for Early In Situ Melanoma Detection Using Acoustic Microscopy and Infrared Spectroscopic Mapping Imaging.Cancers · 2025Article
- Review of Non-Invasive Imaging Technologies for Cutaneous Melanoma.Biosensors · 2025Review
- Four-modal device comprising optical coherence tomography, photoacoustic tomography, ultrasound, and Raman spectroscopy developed for in vivo skin lesion assessment.Biomedical optics express · 2025Article
- Enhancing image reconstruction in photoacoustic imaging using spatial coherence mean-to-standard-deviation factor beamforming.Biomedical optics express · 2024Article
- Diagnostic accuracy of high-frequency ultrasound for cutaneous neoplasms: a narrative review of the literature.Archives of dermatological research · 2024Review
- Non-invasive 3D imaging of human melanocytic lesions by combined ultrasound and photoacoustic tomography: a pilot study.Scientific reports · 2024Article
- Integrating generative AI with ABCDE rule analysis for enhanced skin cancer diagnosis, dermatologist training and patient education.Frontiers in medicine · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate assessment of the size and depth of infiltration is critical for effectively treating and removing skin cancer, especially melanoma. However, existing methods such as skin biopsy and histologic examination are invasive, time-consuming, and may not provide accurate depth results. We present a novel system for simultaneous and co-localized ultrasound and photoacoustic imaging, with the application for non-invasive skin lesion size and depth measurement. The developed system integrates an acoustical mirror that is placed on an ultrasound transducer, which can be translated within a flexible water tank. This allows for 3D (C-mode) imaging, which is useful for mapping the skin structure and determine the invasion size and depth of lesions including skin cancer. For efficient reconstruction of photoacoustic images, we applied the open-source MUST library. The acquisition time per 2D image is <1 s and the pulse energies are below the legal Maximum Permissible Exposure (MPE) on human skin. We present the depth and resolution capabilities of the setup on several self-designed agar phantoms and demonstrate in vivo imaging on human skin. The setup also features an unobstructed optical window from the top, allowing for simple integration with other optical modalities. The perspective towards clinical application is demonstrated.
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