ArticleScientific reports2023
Optimizing the precision of laser speckle contrast imaging.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Loss of Vascular TMEM16A Impairs Cerebral Autoregulation and Exacerbates Ischemia-reperfusion Injury.Translational stroke research · 2026Article
- Real-time wavelet threshold denoising for laser speckle blood flow imaging.Scientific reports · 2026Article
- Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Synthetic X‑ray‑driven tracking and control of miniature medical devices.Nature machine intelligence · 2026Article
- Development of a laser speckle contrast imaging analysis pipeline reveals a triphasic retinal blood flow waveform.Biomedical optics express · 2026Article
- Cardiac pulse transfer along the cerebral microvascular network captured by laser speckle contrast imaging.Biomedical optics express · 2026Article
- Mapping of blood flow and slow speckle tissue dynamics using laser speckle contrast imaging.Biomedical optics express · 2025Article
- Physics-Informed Generative Adversarial Networks for Laser Speckle Noise Suppression.Sensors (Basel, Switzerland) · 2025Article
- Arterial-wall origin and transient dynamics of flow- and vaso-motion activities in the awake mouse brain revealed by laser speckle contrast imaging.Neurophotonics · 2025Article
- Choice of numerical implementation of spatial contrast calculation impacts microcirculation quantitation in laser speckle contrast imaging.Journal of biomedical optics · 2025Article
- Laser speckle contrast imaging with principal component and entropy analysis: a novel approach for depth-independent blood flow assessment.Frontiers of optoelectronics · 2025Article
- Impact of light polarization on laser speckle contrast imaging with a custom phantom for microvascular flow.Scientific reports · 2024Article
- Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow.Nature communications · 2024Article
- Probing diffusive media through speckle differencing.Biomedical optics express · 2024Article
- Validation of multispectral imaging-based tissue oxygen saturation detecting system for wound healing recognition on open wounds.Journal of biomedical optics · 2024Article
- Choosing a polarisation configuration for dynamic light scattering and laser speckle contrast imaging.Biomedical optics express · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Laser speckle contrast imaging (LSCI) is a rapidly developing technology broadly applied for the full-field characterization of tissue perfusion. Over the recent years, significant advancements have been made in interpreting LSCI measurements and improving the technique's accuracy. On the other hand, the method's precision has yet to be studied in detail, despite being as important as accuracy for many biomedical applications. Here we combine simulation, theory and animal experiments to systematically evaluate and re-analyze the role of key factors defining LSCI precision-speckle-to-pixel size ratio, polarisation, exposure time and camera-related noise. We show that contrary to the established assumptions, smaller speckle size and shorter exposure time can improve the precision, while the camera choice is less critical and does not affect the signal-to-noise ratio significantly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.