Evidence map›Paper›PMID 37863929›Full record

ArticleNature communications2023

Dynamic neural representations of memory and space during human ambulatory navigation.

Sabrina L L Maoz, Matthias Stangl, Uros Topalovic, Daniel Batista, Sonja Hiller, Zahra M Aghajan, Barbara Knowlton, John Stern, Jean-Philippe Langevin, Itzhak Fried and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026
    Review
  2. Article
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  6. Review
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  9. Attending to Remember: Recent Advances in Methods and Theory.Current directions in psychological science · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Intracranial substrates of meditation-induced neuromodulation in the amygdala and hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Tell me why: the missing w in episodic memory's what, where, and when.Cognitive, affective & behavioral neuroscience · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sabrina L L MaozDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Matthias StanglDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.ORCID 0000-0002-3331-0510
Uros TopalovicDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.ORCID 0000-0003-4005-7979
Daniel BatistaDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Sonja HillerDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.ORCID 0000-0003-3828-8284
Zahra M AghajanDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Barbara KnowltonDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0002-1532-5081
John SternDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Jean-Philippe LangevinNeurosurgery Service, Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA.ORCID 0000-0002-4447-5257
Itzhak FriedDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.ORCID 0000-0002-5962-2678
Dawn EliashivDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Nanthia SuthanaDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. nanthia@ucla.edu.ORCID 0000-0002-8796-3277

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Neurostimulation and Recording of Real World Spatial Navigation in HumansU01NS117838 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUTHANA, NANTHIA A · 2020 to 2024
$5.3M
Neurostimulation and Recording of Real World Spatial Navigation in HumansU01NS103802 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUTHANA, NANTHIA A · 2017 to 2019
$3.4M
Neural Mechanisms of Spatial Representations Beyond the SelfR00NS126715 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Matthias Stangl · 2024 to 2026
$665k
Neural mechanisms of spatial representations beyond the selfK99NS126715 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI STANGL, MATTHIAS · 2022 to 2023
$232k
Context-based neural representations of space: hippocampal-entorhinal neurophysiology in ambulating humansF30MH125534 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAOZ, SABRINA LEAH LEVY · 2021 to 2024
$181k
NIGMS NIH HHS T32 GM008042NIMH NIH HHS F30 MH125534NINDS NIH HHS K99 NS126715NINDS NIH HHS R00 NS126715NINDS NIH HHS U01 NS103802NINDS NIH HHS U01 NS117838
6 · The paper itself

Abstract

Our ability to recall memories of personal experiences is an essential part of daily life. These episodic memories often involve movement through space and thus require continuous encoding of one's position relative to the surrounding environment. The medial temporal lobe (MTL) is thought to be critically involved, based on studies in freely moving rodents and stationary humans. However, it remains unclear if and how the MTL represents both space and memory especially during physical navigation, given challenges associated with deep brain recordings in humans during movement. We recorded intracranial electroencephalographic (iEEG) activity while participants completed an ambulatory spatial memory task within an immersive virtual reality environment. MTL theta activity was modulated by successful memory retrieval or spatial positions within the environment, depending on dynamically changing behavioral goals. Altogether, these results demonstrate how human MTL oscillations can represent both memory and space in a temporally flexible manner during freely moving navigation.

Indexed as

Memory, EpisodicTemporal LobeElectrocorticographyHippocampusHumansMental RecallSpatial Memory

Identifiers

PMID37863929
PMCPMC10589239

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.